Head, NGS & Bioinformatics Core — Antibody Discovery

AlivaMab Biologics; San Diego (CA); On-site; USD 144,000 - 176,000; Full time

Job summary

AlivaMab Biologics seeks a leader to head the NGS and Bioinformatics Core, overseeing antibody sequencing, repertoire analysis, and AI/ML data workflows. You will collaborate with Protein Sciences, Antibody Engineering, and Discovery teams, ensuring data quality and informing strategic decisions.

Reporting to the Associate Director of Antibody Engineering, you will drive new technology initiatives and data-driven insights.

Qualifications

• PhD in a life sciences field and strong bioinformatics focus.
• 5+ years experience in biotech/pharma or academia with NGS data analysis.
• Hands-on experience applying NGS tools to antibody sequencing and repertoires.
• Proficient Python coding for bioinformatics workflows.
• Experience applying AI/ML to antibody data (sequence/epitope).
• Knowledge of human immune repertoire and immunoglobulin genes.
• Experience with NGS library prep, sequencing platforms, QC.
• Familiarity with single-cell workflows (10X Genomics) a plus.
• Interest in ML/AI for antibody discovery and development.

Responsibilities

• Lead development and implementation of bioinformatics pipelines for antibody sequences and repertoires.
• Apply AI/ML methods for sequence analyses and sequence-epitope prediction.
• Oversee end-to-end NGS workflow from library to downstream analysis; ensure data quality.
• Propose and lead new tech initiatives to expand sequencing capabilities and tools.
• Act as SME in bioinformatics, training cross-functional teams.
• Keep abreast of field announcements; critique claims for management.
• Collaborate with project leads on sequencing and computational reports.
• Interact with external partners to present data and answer questions.
• Maintain scientific independence with proactive communication with stakeholders.
• Generate and manage records in ELN and develop SOPs.

Skills

PhD level biology/biotech

5+ years biopharma/academic bioinfo/NG

Bioinformatics with NGS data analysis

Python coding

AI/ML for antibody analysis

Immunology knowledge

NGS library prep / QC

Single-cell sequencing (10X)

ML for antibody discovery

Education

PhD in Molecular Biology, Biochemistry, Bioinformatics, Computational Biology, or related Life Sciences

Tools

Python

NGS analysis tools

10X Genomics

Job description

AlivaMab Biologics seeks a leader to head the NGS and Bioinformatics Core, overseeing antibody sequencing, repertoire analysis, and AI/ML data workflows. You will collaborate with Protein Sciences, Antibody Engineering, and Discovery teams, ensuring data quality and informing strategic decisions.

Reporting to the Associate Director of Antibody Engineering, you will drive new technology initiatives and data-driven insights.