Hands-On Preformulation Scientist: Discovery to IND

BioTalent; South San Francisco (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

BioTalent seeks a Scientist or Scientist II to lead preformulation activities across innovative small molecule discovery programs. This hands-on role requires roughly 70% lab work and the ability to influence programs from early discovery through IND submission.

You will perform DSC, melting point and solubility analysis, develop HPLC methods, and partner with Discovery, Pharmacology, DMPK, and CMC teams while supporting external CROs.

Qualifications

• PhD, MS or BS with industry experience spanning preformulation in small molecule discovery.
• Strong hands-on bench scientist with deep preformulation expertise.
• Experience characterizing molecules and assessing developability, including IND exposure.
• Exposure to programs progressing from discovery to development is ideal.

Responsibilities

• Lead preformulation studies to support candidate selection and progression.
• Perform hands-on laboratory work including DSC, melting point, solubility and SGF.
• Develop and utilize HPLC-based analytical methods.
• Collaborate with Discovery, Pharmacology, DMPK and CMC teams.
• Support external CROs while maintaining internal scientific ownership.

Skills

Preformulation experience

HPLC methods

Bench work at lab

Small molecule discovery

Developability assessment

IND development exposure

Cross-functional collaboration

Education

PhD + 3-4 years

MS + 6-8 years

BS + 10+ years

Tools

DSC

Melting point analysis

Solubility testing

SGF

HPLC analysis

Job description

BioTalent seeks a Scientist or Scientist II to lead preformulation activities across innovative small molecule discovery programs. This hands-on role requires roughly 70% lab work and the ability to influence programs from early discovery through IND submission.

You will perform DSC, melting point and solubility analysis, develop HPLC methods, and partner with Discovery, Pharmacology, DMPK, and CMC teams while supporting external CROs.