GMP CAR-T Process Development Scientist

Roswell Park Comprehensive Cancer Center; Buffalo (NY); On-site; USD 63,000 - 79,000; Full time

Job summary

Roswell Park Comprehensive Cancer Center is seeking a Research Associate to support GMP CAR T-cell manufacturing process development and transfer from leukapheresis through cryopreservation. You will perform hands-on cell therapy activities using CliniMACS Plus/Prodigy and G-Rex systems, ensuring aseptic technique and GMP compliance.

The role also involves analytical testing like flow cytometry, documenting results for process characterization and technology transfer readiness.

Qualifications

• Master's degree with the equivalent of 18 months of full-time professional research experience or Bachelor's degree with the equivalent of 30 months of full-time professional research experience.
• Degrees must be conferred by an accredited school, college, or university, or by an institution recognized by Roswell Park Comprehensive Cancer Center and/or Health Research Incorporated as adhering to acceptable educational standards.

Responsibilities

• Develop, optimize, and transfer GMP CAR T-cell manufacturing processes from leukapheresis through final product cryopreservation.
• Perform T-cell isolation, activation, genetic modification, expansion, harvesting, formulation, and cryopreservation on automated platforms.
• Conduct analytical testing including flow cytometry to assess cell phenotype, viability, potency, and function.
• Document results to support process characterization, continuous improvement, and manufacturing readiness.

Skills

CAR T-cell workflows

CliniMACS Plus

CliniMACS Prodigy

Cocoon

GMP manufacturing

FDA regulations

Documentation (SOP/BR)

Flow cytometry

Education

Master's degree

Bachelor's degree

Tools

CliniMACS Plus

CliniMACS Prodigy

Cocoon

Job description

Roswell Park Comprehensive Cancer Center is seeking a Research Associate to support GMP CAR T-cell manufacturing process development and transfer from leukapheresis through cryopreservation. You will perform hands-on cell therapy activities using CliniMACS Plus/Prodigy and G-Rex systems, ensuring aseptic technique and GMP compliance.

The role also involves analytical testing like flow cytometry, documenting results for process characterization and technology transfer readiness.