Global Neuroimmunology Clinical Program Lead

AstraZeneca plc; Cambridge (MA); On-site; USD 288,000 - 432,000; Full time

Benefits offered by this job

Short-term incentive bonuses

Equity-based awards

Commissions for sales roles

Qualified retirement programs

Health, dental and vision coverage

Job summary

AstraZeneca plc seeks a Global Clinical Program Lead to own two immune-reset programs in neuroimmunology, from first-in-patient to pivotal stages. You will define strategy, oversee safety, design trials, and manage regulatory interactions with regulators, investigators and patient partners from Cambridge, MA.

You will guide cross-functional teams across Global Project Lead, Regulatory, Patient Safety and Biostatistics to ensure timely delivery of high-impact studies that recalibrate the immune

Qualifications

• MD or equivalent degree; postgraduate specialty training in neurology or related immune-mediated disease.
• Board certification in neurology or related specialty; substantial clinical experience at attending/consultant level.
• 5+ years of clinical drug-development experience in biopharma, with leadership of a clinical program or major studies through key milestones.
• Hands-on leadership of design, delivery and interpretation of multiple industry-sponsored clinical studies.
• Experience leading health-authority interactions and contributing clinical content to regulatory submissions.
• Thorough understanding of full drug development process and biostatistics principles.
• Experience with FDA/EMA/MHRA/ICH GCP requirements for global clinical studies.
• Proven ability to lead complex programs and matrixed teams; strong influencing skills.

Responsibilities

• Define and drive clinical and scientific strategy across two programs, including benefit/risk and Clinical Development Plan.
• Lead endpoint strategy and trial design; ensure studies meet GCP with clear operational plans.
• Oversee program safety strategy and safety oversight at committees and IDMC/DMC.
• Own clinical content for IND/CTA submissions and lead health-authority interactions.
• Present data-driven updates to governance and portfolio committees; align with Global Clinical Head on strategy and investments.
• Build external partnerships with investigators, sites, CROs and patient groups to shape plans.
• Provide matrix leadership to study physicians and clinical scientists across functions.
• Monitor advances in neuroimmunology and translate data into differentiated clinical plans.

Skills

Clinical program leadership

Regulatory interactions

Cross-functional leadership

Global drug development

Stakeholder communication

Education

MD or equivalent + PhD

Neurology specialty board certification

Job description

AstraZeneca plc seeks a Global Clinical Program Lead to own two immune-reset programs in neuroimmunology, from first-in-patient to pivotal stages. You will define strategy, oversee safety, design trials, and manage regulatory interactions with regulators, investigators and patient partners from Cambridge, MA.

You will guide cross-functional teams across Global Project Lead, Regulatory, Patient Safety and Biostatistics to ensure timely delivery of high-impact studies that recalibrate the immune