Genomics Expert for AI Model Training

Obsidian; Philadelphia (Philadelphia County); On-site; USD 70,000 - 110,000; Part time

Job summary

Cincinnatus LLC, in collaboration with a leading AI lab, seeks a Molecular Biology SME to help build foundational AI training data. You design DNA and RNA constructs, validate sequences, and draft rigorous solutions for model evaluation, spanning primers, plasmids, gRNA/sgRNA, mRNA constructs, and codon optimization.

A PhD and hands-on construct design are required, with a strong publication record. Part-time 20h/wk.

Qualifications

• An advanced degree, PhD strongly preferred, in molecular biology, genetics, biochemistry, synthetic biology, bioengineering or a related life science field.
• Hands-on experience designing nucleic acid constructs before the experiment runs, across primers, plasmids and vectors, gRNA and sgRNA, mRNA, and HDR or repair templates, with cloning strategies and codon optimization.
• A strong peer-reviewed publication record, weighted toward first-author work in venues like Nature, Cell, eLife, NAR, PNAS and EMBO Journal; include links.
• Clear career progression.
• Commitment to at least 20 hours a week on weekdays.
• Experience in AI training, model evaluation or data annotation is a plus.
• Strong written communication and ability to explain design reasoning clearly.

Responsibilities

• Work with research and engineering teams to identify where molecular biology reasoning breaks down in models.
• Design hard, domain-relevant tasks and write accurate, well-documented ground-truth solutions for design elements.
• Review tasks and model outputs against expert-quality solutions, providing clear feedback on correctness and rigor.
• Write guidelines and rubrics covering sequence design, homology arms, primer Tm, specificity, codon optimization, and regulatory elements.
• Collaborate with other SMEs to maintain consistency and accuracy of training data.

Skills

DNA construct design

gRNA design

Primer design

qPCR design

Codon optimization

CRISPR editing

mRNA design

Education

PhD in molecular biology

Tools

Gibson assembly

Golden Gate

Gateway cloning

Restriction enzymes

Job description

Cincinnatus LLC, in collaboration with a leading AI lab, seeks a Molecular Biology SME to help build foundational AI training data. You design DNA and RNA constructs, validate sequences, and draft rigorous solutions for model evaluation, spanning primers, plasmids, gRNA/sgRNA, mRNA constructs, and codon optimization.

A PhD and hands-on construct design are required, with a strong publication record. Part-time 20h/wk.