Genomics Bioinformatician II — AI & Multi-Omics Analytics

Mount Sinai; New York (NY); On-site; USD 120,000 - 180,000; Full time

Job summary

Mount Sinai seeks a highly motivated genetic epidemiologist/statistical geneticist to join our computational genomics team as Bioinformatician II. The candidate will develop reproducible, scalable pipelines for genomic and multi-omics analyses on biobank-scale data, including EHR-linked studies, under senior supervision.

Proficiency in R, Python, Unix/Linux shell, and experience with GWAS, PRS, proteomics, and cloud/HPC environments is required.

Qualifications

• MS in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics; PhD preferred.
• 2+ years post-graduate experience with large biological datasets; 4+ years preferred.
• Advanced knowledge of genetics and/or statistical analysis software; experience in programming with R, Python, BioConductor, Perl, C++.

Responsibilities

• Perform large-scale genetic analyses: QC, GWAS, rare variant analyses, PRS, fine-mapping, proteomics, and integrative genomics.
• Work with genetic analysis tools including PLINK, SAIGE, Regenie, BOLT-LMM, GCTA, LDSC, KING, bcftools, samtools, vcftools.
• Conduct proteomic and multi-omics analyses, including pQTL mapping and pathway interpretation.
• Develop reproducible analytical workflows using R, Python, and shell scripting; maintain pipelines in JupyterLab or similar tools.
• Manage and analyze EHR-linked clinical data, integrating phenotype with genomic and proteomic data.
• Apply machine learning approaches for prediction, clustering, and risk modeling; experience with LLMs is a plus.
• Collaborate with multi-institutional consortia; contribute to data harmonization and shared deliverables.
• Prepare visualizations, summaries, and reports for manuscripts and grant applications; ensure rigorous documentation and version control.

Skills

R

Python

Shell scripting

Education

MS in Bioinformatics or related field

PhD preferred

BS with computation experience

Tools

PLINK

SAIGE

Regenie

BOLT-LMM

GCTA

LDSC

KING

bcftools

samtools

vcftools

Job description

Mount Sinai seeks a highly motivated genetic epidemiologist/statistical geneticist to join our computational genomics team as Bioinformatician II. The candidate will develop reproducible, scalable pipelines for genomic and multi-omics analyses on biobank-scale data, including EHR-linked studies, under senior supervision.

Proficiency in R, Python, Unix/Linux shell, and experience with GWAS, PRS, proteomics, and cloud/HPC environments is required.