Full-Stack Software Engineer II — Translational Genomics

Broad Institute; Cambridge (MA); Hybrid; USD 120,000 - 160,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

Life & disability insurance

401(k) retirement plan

FSA/HSA

Paid holidays & time off

Parental leave

Job summary

The Broad Institute is seeking a Software Engineer II to join the Translational Genomics Group in Cambridge, MA, with a hybrid schedule (in-office 1–2 days per week). You will work on seqr, an open-source platform that enables researchers to search large genomic datasets and identify disease-causing variants across the full stack.

You’ll contribute to data pipelines, backend APIs, databases, and user interfaces, growing in responsibility as you gain experience while collaborating with biologists

Qualifications

• Requires 2+ years of related experience with a Bachelor’s degree in related discipline; or 1+ years and a Master’s degree.
• Full-stack experience across backend, database, and frontend layers.
• Strong Python and Javascript skills.
• Ability to work independently and manage your own time effectively.
• Openness to AI-assisted development tools, with good judgment about responsible use around sensitive data.
• Strong communication skills and comfort working with non-technical collaborators.
• Curiosity and adaptability - willingness to learn new domains and technologies on the job.
• Availability to be in the office at least twice per week.

Responsibilities

• Develop features across the full platform: data pipelines (Python/Hail), backend services (Python/Django), databases (PostgreSQL, ClickHouse), and frontend interfaces (React, Redux).
• Assist with deployment related troubleshooting and maintenance.
• Work independently on assigned tasks, growing in scope and complexity over time.
• Collaborate with the lead software engineer on design and architecture, progressively taking on more scoping and design work as you gain experience.
• Maintain and extend data pipelines that ingest genomic data, annotate variants, and load them into analytical databases.
• Build and improve user interfaces that help researchers find disease-causing variants.
• Understand the deployed environment well enough to assist with maintenance and troubleshooting when needed.
• Write tests, participate in code review, and contribute to CI/CD workflows.
• Collaborate with computational biologists, clinicians, and researchers to translate requirements into well-engineered solutions.

Skills

Independent work

Problem solving

Curiosity to learn

Education

Bachelor's degree in related field

Master's degree or PhD considered

Tools

Python

Django

JavaScript

React.js

Redux

PostgreSQL

ClickHouse

Google Cloud Platform

Docker

Terraform

Helm

Bash

Unix/Linux

Git

Job description

The Broad Institute is seeking a Software Engineer II to join the Translational Genomics Group in Cambridge, MA, with a hybrid schedule (in-office 1–2 days per week). You will work on seqr, an open-source platform that enables researchers to search large genomic datasets and identify disease-causing variants across the full stack.

You’ll contribute to data pipelines, backend APIs, databases, and user interfaces, growing in responsibility as you gain experience while collaborating with biologists