Bioinformatics Full-Stack Developer

Signature Science, LLC; Austin (TX); On-site; USD 120,000 - 180,000; Full time

Job summary

Signature Science, LLC seeks a bioinformatics full-stack developer to bridge frontend applications with backend pipelines, delivering software analyzing nucleotide data and producing actionable reports.

The role is full-time, on-site at the Signature Science office in Charlottesville, VA, requiring collaboration across teams and ensuring reproducible pipelines in a robust data environment.

Qualifications

• 5+ years of full-stack developer experience.
• BS/BA in Computer Science, Software Engineering, Bioinformatics, or related field.
• Experience managing and analyzing large-scale genomic datasets.

Responsibilities

• Develop and test full-stack software for analysis and interpretation of whole genome sequencing data.
• Implement and test data processing workflows and automated analysis pipelines.
• Oversee workflow benchmarking and testing, and resolve issues.

Skills

Unix/Linux

C++

UI development

Python

R & tidyverse

CI/CD concepts

communication

time/priority management

project collaboration

Education

BS/BA in Computer Science, Software Engineering, Bioinformatics, or related field

MS or PhD in Computer Science, Software Engineering, Bioinformatics, or related field

Tools

Git

NextFlow

SnakeMake

Docker / containers

AWS / Azure

CI/CD tooling

Job description

The bioinformatics full-stack developer is responsible for building and maintaining a digital bridge between frontend user-facing applications and backend bioinformatics pipelines. This position will oversee the delivery of high-quality software capable of analyzing nucleotide sequence data to produce actionable and user-friendly reports. The ideal candidate will be prepared to oversee and contribute to the development of an integrated software stack for characterization of DNA sequencing data on local hardware systems.

This position is a full-time, on-site role at the Signature Science office in Charlottesville, VA.

Essential Duties and Responsibilities:

• Work with a team to develop and test full-stack software for analysis and interpretation of whole genome sequencing data, including front and back-end software components.
• Implement and test data processing workflows and automated analysis pipelines. Optimize reproducible software pipelines that produce consistent, standardized results.
• Oversee workflow bench marking and testing, identifying inconsistencies and resolving issues.
• Contribute to management of computing hardware, operational logistics, and data warehousing.
• Contribute to the preparation of standard operating procedures, document source code/workflows, and write reports to summarize computational requirements, processing status, and customized analysis results.
• Communicate and interact regularly with project team members and stakeholders.

Required Knowledge, Skills & Abilities:

• Advanced proficiency working in a Unix/Linux environment.
• Advanced proficiency using version control software (e.g., Git) to manage programming code.
• Advanced proficiency with C++.
• Proficiency in developing software user interfaces.
• Proficiency with open-source software, tools, and databases for analyzing next-generation sequencing data.
• Proficiency with at least one programming or run-time interpreted programming language.
• Proficiency with Continuous Integration and Continuous Deployment/Delivery (CI/CD).
• Experience managing a development project including multiple teams.
• Familiarity with issue and project tracking software.
• Skilled at time and priority management.
• Excellent written and oral communication skills.
• Preferred: Proficiency with Python.
• Preferred: proficiency with R, RMarkdown, and the "tidyverse" tools for data analysis.
• Preferred: Experience with NextFlow, SnakeMake, or similar workflow/pipeline management systems.
• Preferred: Proficiency working with and developing using containerization technology.
• Preferred: Familiarity with AWS and/or Azure cloud computing.

Education/Experience:

• Required: 5+ years of previous work experience in a full-stack developer role
• Required: BS/BA in Computer Science, Software Engineering, Bioinformatics, or related field
• Preferred: MS or PhD in Computer Science, Software Engineering, Bioinformatics, or related field
• Preferred: Experience managing and analyzing large-scale datasets produced by DNA sequencing platforms and delivering solutions for managing, visualizing, analyzing, and interpreting genomic data

Clearance:

• This position requires that the candidate be willing and able to complete a successful background screening for a security clearance. Candidates with a current security clearance will receive preference.

Supervisory Responsibilities:

• Serve as a task leader within one or more projects.

Working Conditions/ Equipment:

• Ability to work in varying conditions to include traditional office environments with extended sedentary periods required for code development and testing.