Formulation Scientist II, Injectable Drug Product Development

Alexion Pharmaceuticals, Inc.; New Haven (CT); On-site; USD 90,000 - 120,000; Full time

Job summary

Alexion-AstraZeneca Rare Disease is seeking an Associate Scientist II in the Injectable Drug Product Development (IDPD) team within the PDCS department in New Haven. The role involves experimental work on drug product formulation and development, with a focus on analytical and biophysical comparability testing.

You will design and execute formulation studies, perform physico-chemical characterization, and maintain thorough documentation.

Qualifications

• BS or MS in Biochemistry, Pharmaceutical Science, Chemical Engineering, or relevant field with 2–4 years in pharma/biotech.
• Knowledge of protein/peptide biochemistry, formulation, and stability.
• Experience with iCE/Maurice, HPLC/UPLC (IEX, SEC), DLS, CD, DSC, AUC, NanoTemper.
• Ability to work with minimal supervision in a collaborative setting and meet timelines.
• Strong interpersonal, collaborative and communication skills.
• Proficiency with MS Office (Word, Excel, Outlook, PowerPoint).

Responsibilities

• With some supervision, design and execute formulation and process development studies for clinical biologic candidates
• Execute drug development studies including physico-chemical characterization and stability studies for clinical and commercial drug products
• Characterize conformational and colloidal stability using industry standard methodology (e.g., circular dichroism, differential scanning fluorimetry, analytical ultracentrifugation, size-exclusion chromatography with multi-angle light scattering detection, etc.)
• Maintain organized records and use team tools to keep multiple assignments on track.
• Assist in the preparation of internal technical reports on executed studies with minimal supervision
• Participate in cross-functional development teams

Skills

Protein biochemistry

Formulation knowledge

Analytical testing

Laboratory techniques

Team collaboration

MS Office

Education

BS/MS in Biochemistry, Pharma Sci, Chem Eng, or related field

Tools

iCE/Maurice

HPLC/UPLC (IEX, SEC)

DLS

CD

DSC

AUC

NanoTemper

Job description

Alexion-AstraZeneca Rare Disease is seeking an Associate Scientist II in the Injectable Drug Product Development (IDPD) team within the PDCS department in New Haven. The role involves experimental work on drug product formulation and development, with a focus on analytical and biophysical comparability testing.

You will design and execute formulation studies, perform physico-chemical characterization, and maintain thorough documentation.