FL114 | Cambridge, MA FL114: Scientist, Genomics

Pioneering Medicines; Cambridge (MA); On-site; USD 100,000 - 127,000; Full time

Job summary

FL114, Inc. is seeking an outstanding Scientist to join our Genomics team. We're looking for a skilled, NGS-focused molecular biologist to contribute to the development and advancement of our epigenetic editing programs, from early discovery research to preclinical development and beyond.

The successful candidate will be an essential member of a close-knit team of experimental and computational scientists. We are looking for enthusiastic, detail oriented, adaptive, and highly motivated

Qualifications

• PhD in Molecular Biology, Genomics, or related field, or BS/MS with 7+ years of relevant NGS experience.
• Direct experience performing NGS library prep for Illumina platforms.
• Familiarity with ATAC-seq, RNA-seq, ChIP-seq, Methyl-Seq, and/or 10X Single-cell.
• Deep theoretical and applied knowledge of core molecular biology tenets.
• Demonstrated experience in developing, troubleshooting, and optimizing assays/protocols.
• Experience in an industrial, drug-development environment preferred.
• Immunology-related experience preferred.

Responsibilities

• Execute NGS-based functional genomics assays in a high-throughput production environment that address core R&D needs in cell state mapping and therapeutic molecular validation
• Own the development and optimization of fit-for-purpose NGS solutions and molecular/cellular assay technologies
• Contribute directly at the bench in a small team, with a focus on technical depth

Skills

NGS experience

NGS library prep

ATAC-seq / RNA-seq / ChIP-seq

Illumina platforms

Molecular biology fundamentals

Assay development

Industrial drug development

Immunology

Education

PhD in Molecular Biology/Genomics

BS/MS with 7+ years NGS

Tools

Illumina instruments

Kingfisher automation

Liquid handling systems

Job description

FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment.

About the Role:

FL114, Inc. is seeking an outstanding Scientist to join our Genomics team. We're looking for a skilled, NGS-focused molecular biologist to contribute to the development and advancement of our epigenetic editing programs, from early discovery research to preclinical development and beyond. The successful candidate will be an essential member of a close-knit team of experimental and computational scientists. We are looking for enthusiastic, detail oriented, adaptive, and highly motivated individuals with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team.

Key Responsibilities:

• Execute NGS-based functional genomics assays in a high-throughput production environment that address core R&D needs in cell state mapping and therapeutic molecular validation
• Own the development and optimization of fit-for-purpose NGS solutions and molecular/cellular assay technologies
• Contribute directly at the bench in a small team, with a focus on technical depth

Required Skills & Qualifications:

• PhD. in Molecular Biology, Genomics, or related field (or BS/MS with 7+ years of relevant NGS experience)
• Direct experience performing NGS library prep for Illumina platforms
  • Familiarity with ATAC-seq, RNA-seq, ChIP-seq, Methyl-Seq, and/or 10X Single-cell
  • Familiarity with Illumina instrumentation, liquid handlers, and Kingfisher automation
• Deep theoretical and applied knowledge of core molecular biology tenets
• Demonstrated experience in developing, troubleshooting, and optimizing assays/protocols
• Experience in an industrial, drug-development environment preferred
• Immunology-related experience preferred

About Flagship

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that islargely withoutprecedent. Our team of scientists, entrepreneurial leaders, and professional capital managersare eachaligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people andplanet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.

The salary range for this role is $100,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL114 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL114's good faith estimate as of the date of publication and may be modified in the future.