FL114: Senior Scientist, Therapeutics Engineering

Pioneering Medicines; Cambridge (MA); On-site; USD 126,000 - 160,000; Full time

Benefits offered by this job

Healthcare coverage

Retirement benefits

Job summary

FL114, Inc. in Cambridge, MA is seeking a Senior Scientist to join our Therapeutics Engineering team.

You will contribute to a fast-paced, cross-functional environment, driving development of cutting-edge cellular and molecular assays and supporting multiple therapeutic programs. The role requires a PhD in Cell or Molecular Biology with 2+ years in biotech or pharma, hands-on experience in gene design, library screening, and transfection of mammalian cells.

Qualifications

• PhD in Cell or Molecular Biology or related field with postdoctoral or industry experience preferred.
• Hands-on development of cell-based and library screening assays.
• Experience with DNA asset design, vector construction, and protein expression.

Responsibilities

• Independently conduct and optimize cellular screening assays across cell lines.
• Characterize biologics modalities using cell-based and molecular techniques.
• Drive development of diverse assays and maintain accurate notebooks.

Skills

Molecular biology

Cell culture

RT-qPCR

Cloning

DNA analysis

NGS handling

Gene delivery

CRISPR editing

Data analysis tools

Teamwork

Communication

Education

PhD in Cell or Molecular Biology

Tools

GraphPad Prism

Benchling

SnapGene

Job description

FL114: Senior Scientist, Therapeutics Engineering

Cambridge, MA USA

About FL114

FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment.

About the Role

FL114, Inc. is seeking a Scientist / Senior Scientist to join our integrated Platform as a key contributor in our Therapeutics Engineering efforts. The successful candidate will be an essential member of a close-knit team of experimental and computational scientists driving FL114’s product generation engine and supporting a broad set of therapeutic programs. We are looking for enthusiastic, detail-oriented, adaptive, and highly motivated individuals with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team.

Key Responsibilities

• Independently conduct, optimize and proactively troubleshoot cellular screening assays in a wide range of primary and transformed cell lines.
• Expression and functional characterization of novel biologics modalities using various cell systems and techniques (cell-based assays, RNA/DNA/protein isolation and detection techniques, RT-qPCR, flow cytometry, etc.)
• Drive, pilot, and oversee development of a wide range of cutting-edge assays.
• Design, procurement, and maintenance of plasmids or other relevant materials for cell-based and cell-free assays.
• Identification and management of external partners (CROs, CMOs, etc).

Required Skills

• Execute routine and advanced molecular biology techniques, including plasmid preparation, RT-qPCR, cloning, RNA/DNA extraction, gel electrophoresis, oligo pool work, etc.
• Culture and maintain a wide variety of mammalian cell lines, including transient and stable transfections. Develop cell lines as necessary.
• Analyze and interpret assay data, maintain accurate laboratory notebooks, and communicate results clearly in team meetings.
• Drive optimization and automation of screening protocols, including the use of liquid handling systems and plate readers.
• Experience developing DNA assets for molecular library design.
• Experience with gene delivery technologies (for example LNP, lentivirus, etc.).
• Exposure to CRISPR-based or other gene editing technologies.
• Experience with handling samples for NGS and for its interpretation.
• Familiarity with data analysis tools such as GraphPad Prism, Benchling, SnapGene, etc.
• Adaptive and detail-oriented with excellent time management and organizations skills.
• Exceptional teamwork and communication skills.

Required Qualifications

• PhD in Cell or Molecular Biology, Biochemistry, or related disciplines with 2+ years of relevant experience in biotech or pharma.
• Strong background in cellular and molecular biology with hands-on experience in the development and optimization of cell-based assays and library screening assays.
• Extensive experience in gene design, vector construction, and protein expression.
• Possession of strong communication skills, both written and verbal, to clearly convey results and scientific data to senior leaders, teams and partners.
• Industry experience in drug discovery or pharmaceutical R&D preferred.

About Flagship

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that islargely withoutprecedent. Our team of scientists, entrepreneurial leaders, and professional capital managersare eachaligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people andplanet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Recruitment & Staffing Agencies

Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in manyforms,skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

The salary range for this role is $126,000 - $159,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL114 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL114's good faith estimate as of the date of publication and may be modified in the future.