Expert Pharma Biochemist

Cogent Scientific; Louisville (CO); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

401(k)

Parental leave

PTO and paid holidays

Job summary

Cogent Scientific, an insourced CRO, is seeking an Expert Pharma Biochemist in Louisville, CO, to advance protein biochemistry and structural biology projects. You will work with advanced instrumentation and collaborate with researchers to characterize interactions and prepare samples for cryo-EM.

The role requires a PhD and hands-on experience in expression/purification, biophysical interaction assays, and cryo-EM grid prep.

Qualifications

• PhD in Biochemistry, Molecular Biology, Structural Biology, Biophysics, or related field.
• Hands-on protein biochemistry experience (expression/purification) and protein-protein interaction profiling.
• Familiarity with electron microscope sample prep (negative stain and/or cryo-EM).
• Excellent verbal and written communication; strong teamwork and problem-solving.

Responsibilities

• Characterize protein-protein interactions between targets and engineered binders using biophysical methods.
• Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM).
• Coordinating with internal/external cryo-EM imaging partners on grid screening and data collection.
• Maintaining thorough electronic lab notebook records for reproducibility and traceability.

Skills

Protein biochemistry

Biophysical characterization

Cryo-EM sample prep

Communication

Teamwork & leadership

Education

PhD in Biochemistry or related field

Tools

Mass photometry

SEC/SEC-MALS

SPR

BLI

ITC/AUC

Cryo-EM grid prep

Job description

Cogent Scientific, an insourced contract research organization, is looking for the right people to accomplish our Mission: to support the life sciences industry by cultivating and empowering exceptional scientists to deliver specialized laboratory services that advance research, foster collaboration, and accelerate innovation through quality and a shared commitment to excellence. We can offer you the chance to build on your skills and knowledge while working among experts in their fields and with cutting-edge instrumentation.

Cogent Scientific offers competitive pay, attractive benefits (such as medical/dental/vision insurance; 401(k); parental leave; PTO and paid holidays; etc.) and an exciting work environment. This position may include relocation benefits as well. We aim to recruit the best people who stand out among their peers and embody our Core Values:

• Client Focused: We only succeed when our clients succeed.
• Outstanding: We deliver meticulous results through outstanding performance.
• Good: We act ethically and morally.
• Employee-Centric: We honor and support our employees.
• Nimble: We are prepared to adapt in an ever-changing industry.
• Team-Oriented: We collaborate with each other and with our clients.

We currently have a role available for an Expert Pharma Biochemist.

Job duties include, but are not limited to, the following:

• Characterizing protein-protein interactions between targets and engineered binders using biophysical methods (mass photometry, analytical SEC, SEC-MALS, SPR, or BLI).
• Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization.
• Coordinating with internal/external cryo-EM imaging partners on grid screening and data collection.
• Maintaining thorough electronic lab notebook records for reproducibility and traceability.

Job requirements include, but are not limited to:

• PhD in Biochemistry, Molecular Biology, Structural Biology, Biophysics, or related field.
• Hands-on experience in protein biochemistry (expression/purification, chromatography) and protein-protein interaction characterization (e.g., mass photometry, SPR, BLI, ITC, or AUC).
• Familiarity with electron microscope sample preparation (negative stain and/or cryo-electron microscopy grid prep/screening).

• Excellent communication skills – verbal and written.
• Works well both as a team and as an individual.
• Demonstration of excellent team player skills, very strong attention to detail, very strong problem-solving skills, a high level of learning agility, and the ability to work across functions. The ideal candidate will be enthusiastic and self-motivated, with the leadership and communication skills necessary to operate effectively in a fast-paced multidisciplinary environment with flexibility and an adaptable approach to goal delivery.

This is a day shift position (approx. 8a-5p local time).

Cogent Scientific provides equal employment opportunities to all applicants and does not discriminate based on any legally protected characteristic.

Additionally, if you require a reasonable accommodation during the application or interview process, please let us know.

This job posting will remain open until 9/14/2026 or until a qualified candidate has been selected, whichever comes first.