Expansion Microscopy Scientist — Gel & Imaging Innovator

Convergent Research; Alameda (CA); On-site; USD 100,000 - 170,000; Full time

Benefits offered by this job

Health insurance

Parental leave

Paid time off

401K match

Daily lunches

Wellness stipend

Job summary

E11 Bio in Alameda, California seeks a mission-aligned scientist/engineer for expansion microscopy development and protocol optimization within our production pipeline. You will drive gel performance, QC metrics, and scalable sample production while collaborating with molecular biology, imaging, and computational teams.

The role blends hands-on bench work with quantitative analysis, protocol automation, and cross-disciplinary collaboration to advance toward whole-brain connectomics.

Qualifications

• Ph.D. in biology, chemistry, bioengineering, materials science, mechanical engineering, or related field, or equivalent research/industry experience.
• Strong end-to-end experimental ownership demonstrated.
• Experience with hydrogel chemistry, expansion microscopy, immunohistochemistry, or tissue processing.
• Excellent communication and reproducibility practices.

Responsibilities

• Independently design, coordinate, and execute bench-level expansion microscopy experiments.
• Maintain high-quality gels within the production pipeline.
• Iteratively optimize workflows by sourcing methods from literature.
• Pilot variations to improve signal retention across multi-round cycles.
• Explore diffusion improvements and collaborate with vendors for devices.
• Collaborate with experimental and computational teams to design and analyze experiments.
• Document results and assist in manuscripts and reports.

Skills

Experimental ownership

Communication & collaboration

Quantitative data analysis

Education

Ph.D. in biology/chem/bioengineering

Tools

Spinning-disc confocal microscopy

Light-sheet microscopy

Automation (Arduino/ Raspberry Pi)

Python scripting

Job description

E11 Bio in Alameda, California seeks a mission-aligned scientist/engineer for expansion microscopy development and protocol optimization within our production pipeline. You will drive gel performance, QC metrics, and scalable sample production while collaborating with molecular biology, imaging, and computational teams.

The role blends hands-on bench work with quantitative analysis, protocol automation, and cross-disciplinary collaboration to advance toward whole-brain connectomics.