Entrepreneurial Operating Lead for Biotech NewCos

Flagship Pioneering; Cambridge (MA); On-site; USD 220,000 - 270,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Pioneering’s Summit unit seeks an Operating Principal to launch and scale NewCos. You’ll drive strategy, operations, and corporate development across multiple biotech ventures, while partnering with scientific leadership to translate breakthrough science into scalable impact.

You will shape operating plans, recruit and lead teams, and collaborate with Finance, Legal/IP, and HR to provide top-tier infrastructure across companies.

Qualifications

• 10+ years of experience in biotech, pharma, or life sciences strategy/operations; prior management consulting a plus.
• Proven success in strategic, operational, or corporate development leadership, ideally in early-stage biotech.
• Strong scientific acumen; able to grasp novel science and translate it into plans and execution.
• Track record of building and motivating high-performing teams.
• Skilled communicator, able to influence and inspire across investors, partners, and internal teams.
• Expert problem solver; can bring order to chaos and iterate quickly to find solutions.
• Entrepreneurial, resilient, and hands-on; willing to roll up sleeves to move the ball forward.

Responsibilities

• Lead strategy and operational planning in one or more NewCos.
• Drive corporate development initiatives, including partnerships, financings, and strategic alliances, engaging with Board of Directors and other stakeholders.
• Engage directly with scientists and company leaders to align technical progress with operational goals.
• Recruit, develop, and manage high-performing teams across functions.
• Partner with Flagship central teams to bring best-in-class infrastructure to each company.
• Shape and execute operating and long-range plans, ensuring milestones are met on time and on budget.
• Build strong external relationships with investors, partners, and key opinion leaders.

Skills

Strategic leadership

Operations leadership

Corporate development

Team building

Executive communication

Problem solving

Entrepreneurial mindset

Education

Advanced degree in life sciences or business (PhD, MD, MBA)

Job description

Flagship Pioneering’s Summit unit seeks an Operating Principal to launch and scale NewCos. You’ll drive strategy, operations, and corporate development across multiple biotech ventures, while partnering with scientific leadership to translate breakthrough science into scalable impact.

You will shape operating plans, recruit and lead teams, and collaborate with Finance, Legal/IP, and HR to provide top-tier infrastructure across companies.