Engineer 3

MilliporeSigma; Bedford (MA); On-site; USD 86,000 - 150,000; Full time

Benefits offered by this job

Health insurance

Paid time off

Retirement contributions

Perquisites

Job summary

MilliporeSigma in Bedford, MA seeks an Engineer III to advance bioprocess development for novel modalities. You will plan and run upstream bioreactor studies, interpret data, and collaborate with cross-functional teams to optimize processes for biopharmaceuticals.

The role emphasizes mentoring peers, applying state-of-the-art methods, and ensuring GMP-compliant practices while delivering impactful solutions for CHO-based systems and cell/gene therapies.

Qualifications

• Bachelor’s level or higher degree in life science or engineering with required industry experience.
• Advanced degrees require fewer years of experience as listed.
• Experience with upstream unit operations is preferred.

Responsibilities

• Plan, execute, and interpret laboratory, bench-, and pilot-scale bioreactor studies.
• Evaluate new technologies and optimize processes for emerging modalities.
• Mentor peers and collaborate across downstream processing and PAT teams.

Skills

Bioreactor operations

Upstream bioprocessing

Cell & gene therapy

Process development

Design of experiments

GMP practices

Statistical analysis

Education

Bachelor’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline

Master’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline

PhD in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline

Tools

Single-use bioreactors

Scale-up/scale-down techniques

Job description

Work Your Magic with us! Start your next chapter and join MilliporeSigma.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Your Role
We are seeking a dynamic and agile Engineer III to join the Focused Modalities Applications group within Process Solutions Product Development at MilliporeSigma in Bedford, MA. In this role, you will work within a matrixed team to deliver bioprocessing applications data that helps solve customer challenges and showcases the value of our commercial products for novel modality process optimization & manufacturing. Drawing on expertise in upstream bioreactor operations and bioprocess development, the successful candidate will plan, execute, and interpret laboratory, bench-, and pilot-scale bioreactor studies to evaluate new technologies and optimize processes for emerging modalities such as novel mAbs (bispecifics, multi-specifics) and cell and gene therapies. This position supports team growth by mentoring peers, synthesizing end-user requirements, and expanding capabilities to keep pace with state-of-the-art developments and thought leadership in novel bioprocessing. The successful candidate will have a passion for processdevelopment, strong cross-functional problem-solving skills, and the ability to collaborate with experts in downstreamprocessing and PAT development teams.
Minimum Qualifications
Who You Are:

• Bachelor’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 7+ years of industry experience.

OR

• Master’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 4+ years of industry experience.

OR

• PhD in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 2+ years of industry experience.

Preferred Qualifications

• Experience with planning and executing upstream unit operations including setup and operation of single use bioreactors across multiple scales.
• Strong expertise and hands-on experience in upstream bioprocessing for CHO based systems including novel mAb applications (bispecifics/multi-specifics); knowledge in cell and gene therapy applications a bonus.
• Proficient in optimizing and transferring mammalian bioprocesses from laboratory to large-scale production platforms using scale-up/scale-down approaches and technology transfer.
• Exposure to some of the following analytical techniques: Cell counting, metabolite analysis, protein quantification, glycan and charge variant analysis; flow cytometry, PCR, and ELISA experience.
• Skilled in statistical analysis, experimental design, and design of experiments (DoE) approaches.
• Experience leading small to medium size projects; demonstrated ability to deliver on timelines while balancing scientific rigor and customer urgency.
• Effectively communicates through written reports, oral presentations, application notes, poster presentations, and similar media.
• Familiarity with lab automation and GMP practices.

Pay Range for this position: $85,500 - $149,800 / year
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.
What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!