Downstream Scientist, Viral Vector

Insight Global; Spring House (PA); On-site; USD 70,000 - 95,000; Full time

Job summary

Janssen Pharmaceuticals in Spring House, PA is seeking a hands-on Scientist to support analytical testing and characterization of viral vectors in a high-throughput lab. You will perform DNA/RNA extraction and molecular assays, including ddPCR and qPCR, to support vector development programs.

The ideal candidate has experience with viral vectors and small-scale R&D, and will contribute to cross-functional teams in a fast-paced environment.

Qualifications

• Bachelor's degree in a related field with 2+ years industry experience.
• Chromatography experience using the AKTA equipment.
• Viral vector experience (Lenti, AAV, or similar) and high-throughput environments.
• Small scale (R&D, pilot, discovery) experience (ideally 1L to 2L).

Responsibilities

• Perform DNA and RNA extraction, purification, and quantification from diverse sample types.
• Execute and analyze molecular assays including ddPCR, RT-ddPCR, and qPCR.
• Support viral vector characterization and analytical testing activities.
• Process large sample volumes in a high-throughput laboratory setting.
• Collaborate with scientists and cross-functional teams to meet project goals.

Skills

ddPCR

qPCR

DNA/RNA extraction

Molecular biology assays

High-throughput processing

Viral vector experience

R&D scale experience

Education

Bachelor's degree in Molecular Biology / related field

Tools

AKTA chromatography

Job description

Required Skills & Experience

• Bachelor's degree in Molecular Biology, Biochemistry, Biotechnology, Genetics, Biological Sciences, or related field with 2+ years of industry experience
• Does not have a PhD, will not be considered
• Chromatography experience using the AKTA equipment
• Experience supporting high-throughput sample processing environments.
• Viral Vector experience (can be Lenti, AAV, or similar)
• TFF experience
• Small scale (R&D, pilot, discovery) experience (ideally 1L to 2L)

Hands-on experience performing:

• DNA/RNA extraction and quantification
• ddPCR
• qPCR
• Molecular biology assays in a laboratory setting

Nice to Have Skills & Experience:

• Experience working with lentiviral vector platforms.
• Background supporting cell and gene therapy programs.

Job Description/Day to day:

Janssen Pharmaceuticals is seeking a highly motivated Scientist to support analytical testing and characterization of viral vectors within a dynamic, high-throughput laboratory environment. This individual will play a key role in executing molecular biology assays that support viral vector development and characterization programs.

The ideal candidate is a hands-on molecular biologist with strong experience in DNA/RNA extraction, ddPCR, qPCR, and molecular assay execution. Candidates with experience supporting lentiviral vector platforms and high-volume sample processing environments are especially encouraged to apply.

This position offers the opportunity to work with cutting-edge technologies supporting cell and gene therapy programs while collaborating with cross-functional scientific teams.

Responsibilities:

• Perform DNA and RNA extraction, purification, and quantification from a variety of sample types.
• Execute and analyze molecular assays including:
• Droplet Digital PCR (ddPCR)
• RT-ddPCR
• Quantitative PCR (qPCR)
• Viral genomic RNA (vgRNA) analysis
• Support viral vector characterization and analytical testing activities.
• Process large sample volumes in a high-throughput laboratory setting.
• Utilize laboratory automation tools including liquid handling systems when applicable.
• Troubleshoot assay performance issues and optimize experimental workflows.
• Interpret molecular data and generate accurate, high-quality documentation of results.
• Collaborate with scientists and cross-functional teams to support project goals and timelines.
• Maintain laboratory records and documentation in compliance with established procedures and quality standards.
• Contribute to continuous improvement efforts within laboratory operations.