Senior Scientist, Upstream Viral Process Development

Dispatch Bio; Pennsylvania; On-site; USD 130,000 - 180,000; Full time

Benefits offered by this job

Equity ownership

Medical coverage

Dental / Vision coverage

401(k) plan

Life insurance

Flexible PTO

Job summary

Dispatch Bio in Pennsylvania seeks a Senior Scientist to contribute to upstream viral process development, building manufacturing capabilities and supporting process characterization. Reporting to the Director, Upstream Process Development, you will perform day-to-day lab activities, optimize cultures in shake flasks and bioreactors, and collaborate with research, analytical development, and external partners.

The role requires a PhD/masters with extensive experience in viral vectors and GMP.

Qualifications

• Advanced degree with substantial hands-on experience in viral vector upstream processing.
• Proven experience applying GMP principles to clinical and commercial manufacturing.
• Strong modeling, data analysis and interpretation in process development.

Responsibilities

• Contribute to upstream viral process development and set up vector manufacturing capabilities.
• Develop bench-scale suspension culture processes in shake flasks and bioreactors.
• Perform data review, maintain thorough lab notebooks, and support process characterization.
• Coordinate with research, analytical development, and external CDMO/partners.
• Author technical documents, batch records, SOPs, and regulatory sections as needed.
• Represent the company externally at meetings with collaborators and regulators.

Skills

Viral vector upstream processing

GMP manufacturing

Bioreactor operation

Scale-up / scale-down

Lab data analysis

Cross-functional collaboration

Mentoring junior staff

Education

PhD in bioengineering/biochemical engineering/related field

MS in bioengineering/biochemical engineering

BS in chemical/biochemical engineering or related

Tools

JMP

GraphPad

Microsoft Office

Job description

About us:

Our purpose at Dispatch is to help create a world where all cancer patients can be cured. We’re humbled by the opportunity to work together as a team on some of the most pressing medical challenges of our time.

To achieve our purpose, we are dedicated to engineering a universal treatment across solid tumors. We’re committed to the development of novel therapies, leveraging first-in-class technologies in viral vectors, universal targets, and novel cytokine biology. Our therapeutic approach has the potential to enable us to treat significant numbers of cancer patients and make a real and lasting impact on the world.

Our company was founded on pioneering work carried out in the laboratories of Dr. Carl June (University of Pennsylvania), Dr. Kole Roybal (University of California, San Francisco), Dr. Christopher Garcia (Stanford University) and Dr. Andy Minn (Memorial Sloan Kettering Cancer Center).

At our company, you would become one of our early team members- not only playing a role in meeting our ambitious mission but also building our thriving culture. We are determined to deliver with urgency to discover new solutions and we always stay dedicated to scientific rigor; we have an ownership mindset because each and every one of us is integral to our success. Collaboration is core for us because we believe that by bringing people together with diverse perspectives, we make a stronger whole. And, we show we care about our work and each other by sharing feedback - ultimately in service of our vision to empower people to continue forward with their lives - cancer free.

The role:

Reporting to the Director, Upstream Process Development, the Senior Scientist will contribute to upstream viral process development to bring the company’s pipeline of T cell and viral vector-based products to the clinic. Responsibilities will include, but are not limited to, performing the day-to-day activities of the viral process development lab, building the company’s viral manufacturing capabilities, and executing experiments to support viral process development/characterization. This role will collaborate significantly with research and analytical development teams, as well as contract development and manufacturing organizations.

Key responsibilities:

• Contribute to the setup and organization of the company’s vector process development capabilities.


• Develop bench scale suspension culture processes for viral vector generation within shake flasks and bioreactors through design and execution of experiments to support process characterization, and process transfer activities between the research team, TechOps, and external partners.


• Provide experimental execution, data review and analysis, and maintenance of accurate and detailed lab notebooks.


• Perform day-to-day activities in the vector process development lab including maintaining equipment, ordering materials and managing inventory, and preparing buffers and process aids.


• Author and review technical documents, including but not limited to batch records, SOPs, development reports and process-specific sections of regulatory documents.


• Represent the company externally at meetings (professional associations, with regulatory bodies, etc.).


• Serve as a PD subject matter expert on both internal and external teams (CDMO, material & equipment suppliers, etc.).

Required experience & skills:

• Bachelor’s Degree in Chemical Engineering, Biochemical Engineering/Bioengineering, Biotechnology or related discipline with at least 10 years of relevant experience -OR- Master's Degree with 8 years -OR- PhD with 5 years


• Hands-on experience with viral vector upstream processing, including excellent small-scale aseptic technique and expert understanding of bioreactor operation and control loops


• Experience implementing processes in clinical and commercial manufacturing of cell and gene therapy/biopharma products


• Demonstrated ability to apply knowledge of cell biology, chemical engineering or bioengineering toward process development, scale-up/scale-down and troubleshooting


• Strong scientific reasoning, problem-solving, and applied mathematics and statistics skills, including the ability to break down complex problems into manageable hypotheses


• Proven experience collaborating with internal and external partners


• Ability to balance individual contributions while training and informally mentoring junior colleagues


• Working knowledge of GMP guidelines for clinical and commercial manufacturing


• Proficiency in using Microsoft Word, Excel, Power Point and data analysis/presentation software such as JMP and/or GraphPad


• Excellent interpersonal, verbal and written communication skills


• Strong organizational & problem-solving skills, with excellent attention to detail and the proven ability to collaborate in a dynamic team environment

Preferred experience & skills:

• Hands-on plasmid manufacturing experience or oversight of external plasmid manufacturing partners


• End-to-end experience in Lentivirus and Adenovirus development and manufacturing


• High-throughput bioreactors systems


• Drafting CMC sections for INDs


• Use of Artificial Intelligence (AI) to develop efficiencies and assist in tackling complex problems

Our values:

Our values guide everything we do. While capabilities and skills are vital, understanding how a potential new colleague would embody our values is central to our hiring decisions.

Determined to deliver:

By working with focus and passion, we can provide patients with the solutions they need.

Own every outcome:

We can reach new heights when we stay centered on our shared success.

Collaboration at the core:

When we band together, our work is better.

Feedback is fundamental:

Constructive and authentic positive feedback may be difficult to master but it is vital to our success.

Working here:

• We offer a highly competitive compensation package with meaningful ownership through equity


• Excellent coverage for medical, vision, and dental


• 401(k) with generous contribution


• Life insurance


• Flexible PTO policy


• Additional substantial benefits

We are an equal opportunity employer.

We do not discriminate on the basis of race, religion, gender, sexual orientation, age, marital status, veteran status, disability status, national origin, or any characteristic protected under applicable law.