Downstream Process Scientist, Viral Vector Purification
Eli Lilly and Company
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Benefits offered by this job
Job summary
Eli Lilly and Company is seeking a highly motivated Scientist to join the Downstream Process Development team in Boston. The role leads development and optimization of downstream purification workflows for viral vectors, with hands-on expertise in ultracentrifugation, chromatography, and TFF/UFDF.
The successful candidate will independently design experiments, collaborate across functions, and drive process improvements, while mentoring junior staff and contributing to technology transfers and
Qualifications
- Bachelor’s degree in biology, biochemistry, chemical engineering, biotechnology, or related scientific field.
- 5+ years (master’s/PhD) with 3+ years of relevant downstream process development experience in industry.
- Experience with downstream purification technologies including ultracentrifugation, chromatography, and TFF.
Responsibilities
- Lead development, optimization, and scale‑up of downstream purification workflows for viral vectors.
- Design and implement purification strategies using iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion‑exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
- Lead AKTA‑based chromatography workflow development and process intensification initiatives.
- Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
- Independently design experiments, analyze data, interpret results, and present technical conclusions to multi‑functional teams and leadership.
- Drive troubleshooting, process characterization, and process robustness studies.
Skills
Education
Tools
Job description
Eli Lilly and Company is seeking a highly motivated Scientist to join the Downstream Process Development team in Boston. The role leads development and optimization of downstream purification workflows for viral vectors, with hands-on expertise in ultracentrifugation, chromatography, and TFF/UFDF.
The successful candidate will independently design experiments, collaborate across functions, and drive process improvements, while mentoring junior staff and contributing to technology transfers and
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