Associate Scientist - Downstream Process Development

100 Eli Lilly and Company; Boston (MA); In loco; USD 72.000 - 189.000; Tempo pieno

Vantaggi offerti da questo lavoro

401(k)

Pension

Vacation benefits

Medical benefits

Dental benefits

Vision benefits

Prescription drug benefits

Flexible benefits

Life insurance

Leave benefits

Well‑being benefits

Descrizione del lavoro

Eli Lilly and Company is seeking a highly motivated Scientist to join the Downstream Process Development team in Boston. The role leads development and optimization of downstream purification workflows for viral vectors, with hands-on expertise in ultracentrifugation, chromatography, and TFF/UFDF.

The successful candidate will independently design experiments, collaborate across functions, and drive process improvements, while mentoring junior staff and contributing to technology transfers and

Competenze

• Bachelor’s degree in biology, biochemistry, chemical engineering, biotechnology, or related scientific field.
• 5+ years (master’s/PhD) with 3+ years of relevant downstream process development experience in industry.
• Experience with downstream purification technologies including ultracentrifugation, chromatography, and TFF.

Mansioni

• Lead development, optimization, and scale‑up of downstream purification workflows for viral vectors.
• Design and implement purification strategies using iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion‑exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
• Lead AKTA‑based chromatography workflow development and process intensification initiatives.
• Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
• Independently design experiments, analyze data, interpret results, and present technical conclusions to multi‑functional teams and leadership.
• Drive troubleshooting, process characterization, and process robustness studies.

Conoscenze

Downstream purification

AKTA systems

Unicorn software

TFF/UFDF

Density gradient ultracentrifugation

Process characterization

Multi-functional collaboration

Leadership

Formazione

Bachelor’s degree in biology/biochemistry/chemical engineering/biotechnology or related field

Master’s or PhD with 3+ years in industry

Strumenti

Unicorn software

AKTA systems

Descrizione del lavoro

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. We are seeking a highly motivated Scientist to join the Downstream Process Development team. The successful candidate will lead development and optimization of downstream purification processes supporting viral vector programs from research through preclinical development. The ideal candidate will possess deep technical expertise in downstream purification technologies including ultracentrifugation, chromatography, and tangential flow filtration (TFF), with demonstrated experience driving process development strategies, platform development initiatives, technology implementation, and multi‑functional collaboration. This role requires strong scientific leadership, hands‑on technical capability, and the ability to independently lead complex purification development activities in a fast‑paced environment.

Key Responsibilities

• Lead development, optimization, and scale‑up of downstream purification workflows for viral vectors.
• Design and implement purification strategies using Iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion‑exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
• Lead AKTA‑based chromatography workflow development and process intensification initiatives.
• Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
• Independently design experiments, analyze data, interpret results, and present technical conclusions to multi‑functional teams and leadership.
• Drive troubleshooting, process characterization, and process robustness studies.
• Collaborate closely with upstream, analytical, manufacturing, and external partners to support program work and timelines.
• Support technology transfer, process documentation, and development reports.
• Lead development and optimization of TFF/UFDF workflows for concentration, buffer exchange, formulation, and process scalability.
• Mentor junior scientists/engineers and provide technical guidance across purification activities.
• Contribute to implementation of new purification technologies, automation tools, and continuous process improvements.
• Ensure compliance with safety, documentation, and quality standards.

Basic Qualifications

• Bachelor’s degree in biology, biochemistry, chemical engineering, biotechnology, or related scientific field.
• 5+ years (master’s/PhD) with 3+ years of relevant downstream process development experience in industry.

Additional Skills/Preferences

• CsCl and iodixanol ultracentrifugation
• Affinity chromatography
• Ion‑exchange chromatography
• TFF/UFDF operations including concentration, diafiltration, and formulation development
• AKTA systems and Unicorn software
• Strong understanding of process scale‑up, platform development, and purification process characterization.
• Experience analyzing purification performance and product quality attributes using relevant analytical methods.
• Experience in AAV downstream process development and capsid enrichment workflows.
• Experience with automated chromatography systems and process intensification strategies.
• Experience supporting technology transfer and manufacturing readiness activities.
• Familiarity with GMP development environments and regulatory expectations.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

• company-sponsored 401(k)
• pension
• vacation benefits
• medical benefits
• dental benefits
• vision benefits
• prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.

The anticipated wage for this position is $72,000 - $189,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!