Downstream Process Scientist

Eurofins USA PSS Insourcing Solutions; Malvern (Chester County); On-site; USD 70,000 - 90,000; Full time

Job summary

A leading company in biopharmaceutical development is seeking a candidate for the role focused on scale-up and execution of DSP operations. Candidates will handle pilot-scale work, optimize processes for protein therapeutics, and contribute to technical documentation. Ideal applicants are organized with experience in chromatography and possess a BS degree in a scientific discipline. Competitive benefits include comprehensive medical coverage and 401(k) matching.

Benefits

Comprehensive medical coverage

Dental and vision options

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Qualifications

• Experience with DSP purification of protein therapeutics (antibodies).
• Preferred experience with scale-up/down of DSP for biologics.
• Ability to manage multiple projects under supervision.

Responsibilities

• Conduct pilot-scale DSP operations and technical documentation.
• Analyze and report data findings to project teams.
• Ensure processes represent internal and external manufacturing.

Skills

Organization

Data reporting

Team collaboration

Education

BS in scientific related discipline

Tools

Chromatography

Filtration systems

Job description

The candidate for this position will work as a member of a small team to perform scale-up/scale-down development of therapeutic biologics with strong emphasis on API proteins within the Large-Scale Development & Operations downstream (DSP) group in Malvern, PA. The candidate’s primary responsibilities will include a component of pilot-scale DSP operations execution, DSP data acquisition and modeling, and optimizing the process steps to be representative of the target process scale to ensure right first time technical transfers.

This will include:

• Pilot-scale and occasional laboratory work with chromatographic purification and several types of filtration systems
• Record and analyze data, verify data integrity and accuracy, and report/summarize findings to the project development teams
• Design experiments to optimize DSP operations within the Large-Scale Development & Operations DSP group to ensure that they are representative of internal and external manufacturing sites
• Draft technical documents, SOPs, and work instructions
• Work in a team environment as well as contributing individually to meet project timelines and objectives
• Qualifications

  Qualifications

  • Minimum of BS in scientific related discipline is required.
  • Knowledge of and hands-on experience with DSP purification (chromatography, filtration) of protein therapeutics (such as antibodies) is required.
  • Experience with scale-up/down of DSP, and/or execution at pilot or manufacturing scales for biologics manufacture is preferred.
  • Exposure to analytical method development for in-process methods is preferred.
  • The candidate must be highly organized and capable of managing/pursuing multiple projects with some supervision.
  • Experience maintaining written records of work in the form of (electronic) notebooks, technical reports and protocols is preferred.
  • Data reporting, ability to present findings to management, and experience with team-based collaborations is required.

  Additional Information

  • Position is full-time, Mon-Fri 9am-5pm. Candidates currently living within a commutable distance of Malvern, PA are encouraged to apply.

  • Excellent full time benefits including comprehensive medical coverage, dental, and vision options

  • Life and disability insurance

  • 401(k) with company match

  • Paid vacation and holidays

  Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.