Downstream Engineer III

Scorpion Therapeutics; Lexington (MA); On-site; USD 110,000 - 150,000; Full time

Job summary

Scorpion Therapeutics seeks an Engineer III in Downstream Process Development to drive chromatography, harvest, ultrafiltration, and viral clearance experiments. You will support bench-to-pilot scale work on early- and late-stage programs, maintain equipment, and document results in ELN with clear data presentation.

You will plan larger experiments with senior engineers, analyze results, and prepare technical summaries while adhering to quality and safety standards and pursuing continuous

Qualifications

• Bachelor’s or Master’s degree in chemical engineering, chemistry, biochemistry, biotechnology, or related field with relevant lab experience.
• Experience with chromatography, harvest, ultrafiltration/diafiltration, and viral clearance steps.
• Experience in process development, protein purification, or related lab setting.
• Familiarity with lab control systems and basic data analysis.
• Experience using electronic laboratory notebooks and documenting results clearly.

Responsibilities

• Execute chromatography, harvest, ultrafiltration/diafiltration, and viral clearance experiments.
• Support downstream biotherapeutics process development across multiple scales.
• Maintain laboratory equipment and instrument readiness.
• Plan and execute larger experiments with senior engineers.
• Document experiments in ELNs and maintain complete records.
• Perform basic data analysis and support study conclusions.
• Prepare technical summaries and study updates.
• Follow lab procedures, quality, and safety requirements.
• Identify opportunities to improve workflows and data capture.
• Assist with small projects and guide junior team members.

Skills

Chromatography

Harvest operations

Ultrafiltration

Diafiltration

Viral clearance

Data analysis

Technical writing

Lab practices

AI-enabled data analysis

ELN familiarity

Education

Bachelor’s degree with 2+ years relevant experience, or Master’s degree with relevant experience

Tools

Electronic Lab Notebook (ELN)

Job description

Downstream Process Development, Engineer III

Responsibilities

• Execute chromatography, harvest operations, ultrafiltration/diafiltration, and viral clearance experiments (may also support bioconjugation).
• Support downstream biotherapeutics process development across micro, bench, and pilot scales for early- and late-stage programs.
• Maintain laboratory equipment and support instrument readiness.
• Plan and execute larger experiments with more senior process engineers.
• Document experiments in electronic laboratory notebooks; maintain timely, complete records.
• Perform basic data analysis and support study conclusions.
• Prepare technical summaries and written study updates.
• Follow established lab/process development procedures, including quality and safety requirements.
• Identify continuous improvement opportunities in workflows, data capture, and experimental execution.
• Assist with small projects/tasks under close supervision; advise peers/junior team members when needed.

Qualifications/Requirements

• Bachelor’s degree with 2+ years relevant experience, or Master’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or related field.
• Experience with chromatography, harvest, ultrafiltration/diafiltration, and viral clearance steps.
• Some relevant experience in process development, protein purification, or related lab setting.
• Experience with basic bioprocess control systems.
• Experience using electronic laboratory notebooks.
• Ability to perform basic data analysis and present results clearly in writing.
• Familiarity with technical writing.
• Understanding of lab practices, process development methods, and quality requirements.
• Ability to follow detailed procedures and maintain accurate records under close supervision.
• Comfort with emerging digital tools and AI-enabled processes for data analysis/documentation/workflow improvement.