Downstream Bioprocess Scientist: mAb Scale-Up & Transfer

Merck; West Point (PA); On-site; USD 87,000 - 137,000; Full time

Benefits offered by this job

Healthcare benefits

401(k) retirement plan

Paid holidays

Vacation time

Sick days

Job summary

Merck is seeking a motivated scientist/engineer to join the Bioprocess Drug Substance Commercialization group. You will lead downstream processing experiments for monoclonal antibody products and contribute to technology transfer and in-line support of biologics.

The role involves hands-on lab work, collaboration with manufacturing teams, and authoring technical documents to support PPQ, licensure, and regulatory submissions at a premier biopharmaceutical company.

Qualifications

• Bachelor's degree or higher in Chemical Engineering, Chemistry, Biology or a comparable discipline.
• 2+ years of experience with downstream processing of monoclonal antibody (mAb) products or similar products in a laboratory or manufacturing setting, including unit operations such as membrane filtration, preparative chromatography, ultrafiltration or tangential flow filtration, and viral clearance.
• Mechanistic understanding of downstream processing separation sciences.
• Ability to execute experiments independently in a manner that meets quality and timeline expectations.
• Well-developed communication, organizational, and problem-solving skills, with an attention to detail.

Responsibilities

• Lead the execution of hands-on experiments in biologics downstream processing, including lab-scale process characterization, pilot-scale process development, and process scale-up/scale-down model development.
• Collaborate with commercial manufacturing teams as a process sciences representative to support facility start-up and in-line support activities, including on-the-floor support for drug substance manufacturing as needed.
• Author and/or review technical documents to support Process Performance Qualification (PPQ) and licensure.

Skills

Downstream processing

Lab-scale experiments

Process scale-up

Education

Bachelor's degree in Chemical Engineering, Chemistry or Biology

Tools

Membrane filtration

Preparative chromatography

Ultrafiltration / tangential flow filtration

Job description

Merck is seeking a motivated scientist/engineer to join the Bioprocess Drug Substance Commercialization group. You will lead downstream processing experiments for monoclonal antibody products and contribute to technology transfer and in-line support of biologics.

The role involves hands-on lab work, collaboration with manufacturing teams, and authoring technical documents to support PPQ, licensure, and regulatory submissions at a premier biopharmaceutical company.