Discovery Synthesis & Purification Co-op

Wave Life Sciences; Lexington (MA); On-site; USD 33,000 - 44,000; Full time

Benefits offered by this job

Medical, dental, vision insurance

401(k) with matching

Employee Stock Purchase Program

Generous paid time off

Job summary

Wave Life Sciences is seeking a highly motivated co‑op student in Lexington, MA to gain exposure to oligonucleotide synthesis, formulation, purification and analysis. Training will cover multiple lab techniques and instrumentation, preparing you for future industry or academia opportunities.

This position emphasizes organization, attention to detail and teamwork in a fast-paced biotech environment, with coursework in organic/biochemistry/analytical chemistry preferred.

Qualifications

• Lab safety policies adherence.
• Effective and timely communication with stakeholders.
• Attention to detail and well organized.
• Inquisitive student with a positive attitude and willingness to improve efficiencies.

Responsibilities

• Perform downstream processing of oligonucleotides synthesized at various scales using purification modalities (AEX chromatography, SEC).
• Learn AKTA Unicorn software to assist in developing new methods/gradients.
• Characterize compounds using analytical instrumentation (UV, pH, UPLC, LC-MS).
• Operate and maintain lab equipment (synthesizers, ÄKTA purifiers, UPLC, LC-MS, Nanodrop).
• Maintain timely written and electronic records of protocols and data per company policy.
• Potential to learn synthesis of oligonucleotides on MM12, MM192, and AKTA synthesis systems if timing allows.

Job description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Wave Life Sciences, a biotech oligonucleotide therapeutics company, seeks a highly motivated co‑op student to join its team of scientists in Lexington, Massachusetts. This co‑op student will gain exposure to areas of oligonucleotide synthesis, formulation, purification, and analysis. The co‑op will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity for future entrance into industry or academia. This is an ideal position for any student with strong organizational skills and attention to detail who thrives in a team‑oriented, fast‑paced and multi‑disciplinary biotech environment. Completion of coursework in organic chemistry, biochemistry, analytical chemistry with laboratory experience is preferred.

Responsibilities

• Perform downstream processing of oligonucleotides synthesized at various scales, utilizing various purification modalities, but specifically Anion Exchange (AEX) chromatography and size exclusion chromatography (SEC).
• Learn the AKTA Unicorn software to assist in developing new methods/gradients
• Characterize compounds using analytical instrumentation i.e., UV, pH, UPLC and LC-MS
• Operate and maintain lab equipment such as synthesizers, ÄKTA purifiers, UPLC, LC-MS, Nanodrop, and other analytical instrumentation
• Maintain timely, detailed written and electronic records of experimental protocols and data in accordance with company policy
• Potential to learn synthesis of oligonucleotides on the MM12, MM192 and AKTA synthesis systems if timing allows

Qualifications

• Strict adherence to lab safety and personal protective equipment policies
• Effective and timely communication skills both interdepartmentally and with vested stakeholders, including presenting scientific data
• Attention to detail and well organized
• An inquisitive student with a positive attitude with a desire to succeed and promote change to improve efficiencies

Pay Range Disclosure Statement

$24 USD - $32 USD

Benefits

• company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program.

Wave Life Sciences offers equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

Data Privacy and Your Information

Wave Life Sciences is committed to respecting your privacy. We do not sell or rent personal information to third parties for marketing purposes.Any Personal Information you share with us will be used for business purposes, such as communication with you, and handled in accordance with Wave’s Privacy Policy, Notice, Statements, and Additional Information. Wave collects, evaluates and retains candidate data for the legitimate interest of selecting a candidate for employment or contract purposes. Such data will be kept for no longer than necessary to carry out those purposes, unless you consent for your information to be retained up to an additional three (3) years for consideration for future opportunities at Wave. Any requests related to your Personal Information may be electronically submitted to Wave’s Data Protection Officer at https://wavelifesciences.com/privacy/.