Discovery Scientist I - Structural Biology and Biochemistry

Cleveland Clinic; Cleveland (OH); On-site; USD 48,000 - 72,000; Full time

Job summary

Cleveland Clinic’s Center for Experimental Therapeutics seeks a Discovery Scientist to join a cross-functional team, advancing early drug discovery projects toward clinical development. You will design and execute experiments, analyze data, and contribute to scientific presentations in a non-patient-facing role.

You will work with mentors to develop expertise in modern drug discovery methods, maintain electronic notebooks, and participate in team decisions within a collaborative environment at

Qualifications

• Bachelor's degree in a relevant scientific field.
• 0–2 years of relevant experience.
• Excellent communication and interpersonal skills.

Responsibilities

• Perform SOPs with minimal supervision.
• Demonstrate quality and accuracy in daily work.
• Follow lab safety and compliance policies.
• Collaborate with a mentor to design and execute experiments.
• Assist with troubleshooting and identifying laboratory solutions.
• Calculate, record, and report experimental data.
• Maintain electronic laboratory notebooks with minimal supervision.
• Maintain laboratory inventories and order materials as needed.
• Express and purify recombinant proteins to support studies.
• Assist with automated assays and high-throughput screening.

Skills

Communication skills

Interpersonal skills

Education

Bachelor's degree in a relevant scientific field

Job description

Join Cleveland Clinic’s Main Campus where research and surgery are advanced, technology is leading-edge, patient care is world class and caregivers are family. Here, you will work alongside a passionate and dedicated team, receive endless support and appreciation, and build a rewarding career with one of the most respected healthcare organizations in the world.

Cleveland Clinic’s Center for Experimental Therapeutics brings together experts and cutting-edge technologies in small molecules and biologics to translate basic biological discoveries into patient-focused therapeutics. As a Discovery Scientist, you will work within a highly integrated, cross-functional research team to advance early drug discovery projects toward clinical development, using automated systems and state-of-the-art technologies commonly found in the pharmaceutical industry. In this non-patient-facing role, you will collaborate with experienced scientific mentors to design and execute experiments, develop expertise in modern drug discovery methods, analyze data, and contribute to scientific presentations. You will work in a collaborative environment where diverse perspectives and insights are valued in team decision-making.

A caregiver in this role works days from 8:00 a.m. – 5:00 p.m.

A caregiver who excels in this role will:

• Perform required Center standard operating procedures (SOPs) with minimal supervision.
• Demonstrate consistent quality and accuracy in daily work.
• Follow laboratory safety and compliance policies and procedures.
• Collaborate with an experienced scientific mentor to design and execute experiments.
• Assist with troubleshooting and identifying potential solutions to laboratory challenges.
• Calculate, record, compile, and report experimental data.
• Maintain electronic laboratory notebooks with minimal supervision.
• Address problems related to daily laboratory activities.
• Maintain laboratory inventories and order materials as needed.
• Demonstrate proficiency in the use of laboratory instruments and equipment.
• Maintain instrumentation and equipment for daily use in accordance with training and established SOPs.
• Contribute to publications, manuscripts, and patent applications.
• Assist in training technicians, trainees, and students as needed.
• Participate in team meetings and collaborate within a multidisciplinary environment, including with Cleveland Clinic collaborators, to discuss research and contribute ideas.
• Perform routine tissue culture.
• Help establish and routinely perform automated cell-based assays in accordance with SOPs.
• Help establish chemical biology assays for target engagement studies.
• Assist with compound management for high-throughput screening using automated liquid handlers, automated compound storage systems, and integrated informatics systems to track compounds.
• Manage laboratory reagents and supplies and maintain a clean, safe, and organized working environment.
• Express and purify recombinant proteins to support biochemical and structural biology studies.
• Help establish and routinely run automated biochemical assays using standard operating procedures (SOPs).
• Perform automated protein crystallography screens.
• Assist with routine structure solution of ligand-bound protein complexes.
• Maintain an electronic laboratory notebook, manage laboratory reagents and supplies, and ensure a clean, safe, and organized working environment.
• Perform other duties as assigned.

Minimum qualifications for the ideal future caregiver include:

• Bachelor's degree in a relevant scientific field
• Entry Level (0-2 years) of relevant experience
• Excellent communication skills (both verbal and technical) and strong interpersonal skills

Preferred qualifications for the ideal future caregiver include:

• Undergraduate thesis or research experience in an Organic Chemistry Lab with exposure to synthetic methodology or synthesis or research experience in a biology or Biochemistry lab or other related experience with demonstrated leadership
• Prior hands-on laboratory experience in cell biology or molecular biology

Physical Requirements:

• May be exposed to hazardous biological, vaporous and odorous materials
• Manual and visual dexterity required.
• Ability to follow written and verbal instructions.
• Continuous lifting, standing and walking.

Personal Protective Equipment:

• Follows standard precautions using personal protective equipment as required.

Pay Range

Minimum Annual Salary: $47,530.00

Maximum Annual Salary: $72,475.00

The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking factors into consideration such as the candidate’s work history, experience, skill set and education. The pay range displayed does not include any applicable pay practices (e.g., shift differentials, overtime, etc.). The pay range does not include the value of Cleveland Clinic’s benefits package (e.g., healthcare, dental and vision benefits, retirement savings account contributions, etc.).