Discovery Immunology Research Scientist

Vertex Pharmaceuticals; Seattle (WA); On-site; USD 106,000 - 158,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

Paid time off

Educational assistance

Commuting subsidy

Matching charitable donations

401(k)

Job summary

Vertex Pharmaceuticals is seeking a Scientist for the Discovery Immunology Group in Seattle to advance protein therapeutics for autoimmune diseases. The role involves designing, executing, and analyzing experiments on immune mechanisms, target validation, and therapeutic development in a collaborative lab setting. A Ph.D.

or equivalent with relevant post-doctoral or industry experience is typical. You will work with primary human immune cells, perform multicolor flow cytometry and Incucyte

Qualifications

• Hands-on tissue culture experience with primary human immune cells and cell lines.
• Solid immunology knowledge, esp. T and B cell biology, with eagerness to learn.
• Ability to design and execute complex experiments in disease contexts.
• Experience with cell-based immunology assays including multicolor flow cytometry and Incucyte.
• Experience measuring soluble analytes (ELISA or MSD).
• Strong problem-solving and independence, with ability to work in a team.
• Excellent organization and attention to detail.

Responsibilities

• Isolate, culture, and manipulate primary human immune cells and cell lines.
• Design and execute experiments to interrogate immune cell phenotype and function.
• Troubleshoot experiments and optimize protocols.
• Collect, analyze, and interpret data with detailed records.
• Collaborate with discovery teams to achieve project goals.
• Prepare data for internal reports and presentations.
• Perform other duties as needed.

Skills

Immune cell culture

Flow cytometry

Incucyte assays

ELISA / MSD

Data analysis & interpretation

Laboratory documentation

Collaborative work

Education

Ph.D. in molecular biology / cell biology / biochemistry

M.S. in molecular biology / cell biology / biochemistry

B.S. in molecular biology / cell biology / biochemistry

Tools

Incucyte

MSD ELISA platforms

Job description

General Summary

The Discovery Immunology Group is seeking a highly motivated Scientist to assist in the discovery and development of novel protein therapeutics to treat patients with autoimmune disease. This is a laboratory-based role where the successful candidate will contribute directly to research efforts by designing, executing, and analyzing experiments related to immune mechanisms, target validation, and therapeutic development. The position requires strong attention to detail and ability to multitask while working in a highly collaborative environment.

Key Duties and Responsibilities

• Isolate, culture, and manipulate primary human immune cells and cell lines.
• Design and execute experiments to interrogate immune cell phenotype and function, including cell-based multicolor flow cytometry and Incucyte assays.
• Troubleshoot experiments and optimize protocols.
• Collect, analyze, and interpret experimental data while maintaining accurate and detailed laboratory records.
• Collaborate with scientists across discovery teams to achieve project goals.
• Prepare data for internal reports and presentations for internal meetings.
• Perform other duties as needed.

Knowledge and Skills

• Hands-on tissue culture experience, including the isolation and maintenance of primary human immune cells and human cell lines.
• Solid understanding of immunology, particularly T and B cell biology, and eagerness to acquire new skills.
• Ability to design and execute complex experiments in disease-relevant contexts.
• Experience with a variety of cell-based immunology assays to interrogate immune cell phenotype and function including multicolor flow cytometry and Incucyte assays.
• Experience measuring soluble analytes by methods such as ELISA or ECLIA (MSD).
• Critical thinking and self-reliance to solve tasks independently or ask questions.
• Strong organizational skills and attention to detail.
• Willingness and ability to work in a highly collaborative environment.

Education and Experience

• Ph.D. (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 0-3 years of relevant post-doctoral employment experience, or
• Masters Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 3+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 6+ years of relevant employment experience

Pay Range

$105,600 - $158,400

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

• From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• educational assistance programs including student loan repayment
• a generous commuting subsidy
• matching charitable donations
• 401(k)