Exploratory Biology Research Scientist

Vertex Pharmaceuticals Incorporated; San Diego (CA); On-site; USD 106,000 - 158,000; Full time

Benefits offered by this job

Annual bonus

Annual equity awards

Paid time off

Commuting subsidy

401(k)

Job summary

Vertex Pharmaceuticals Incorporated in San Diego, CA, seeks a Research Scientist, Exploratory Biology to identify new disease opportunities and design rigorous experiments advancing disease biology and target mechanisms.

You will develop biochemical and cellular assays, analyze complex data, and present clear hypotheses to multidisciplinary teams and leadership in a fast-paced discovery environment. This on-site role emphasizes independence and collaboration.

Qualifications

• Design and execute rigorous experiments with scientific rigor.
• Develop measurable biochemical and cellular assays.
• Stay current with literature and translate findings into plans.

Responsibilities

• Identify and evaluate novel disease opportunities aligned with research strategy.
• Design and execute technically rigorous experiments to probe biology and targets.
• Analyze complex data and translate findings into hypotheses and next steps.
• Troubleshoot studies and refine methods to improve quality and impact.
• Prioritize activities across projects and align with team goals.
• Survey literature and integrate new concepts into research plans.
• Prepare clear scientific reports and presentations for teams and leadership.
• Collaborate effectively in a cross-functional, fast-paced environment.

Skills

Disease biology

Experimental design

Biochemical assays

Cellular assays

Data analysis

Scientific writing

Education

PhD in Cellular Biology or related

MS with 3+ years experience

BS with 6+ years experience

Job description

Job Description

The Research Scientist, Exploratory Biology will be responsible for identifying new disease opportunities that align with Vertex research strategy, designing and executing focused research studies to advance understanding of disease biology and target mechanisms, and contributing to informed go/no go decisions. This role will contribute to the development of biochemical and cellular assays, generate high-quality experimental data, and help shape new scientific directions through rigorous analysis and creative problem solving. The successful candidate will work with a strong degree of independence while collaborating effectively across multidisciplinary teams in a fast-paced discovery environment.

Key Duties & Responsibilities

• Identify and evaluate novel disease opportunities that align with Vertex research strategy.
• Design and execute technically rigorous experiments to investigate disease biology and target mechanisms.
• Analyze complex experimental data and translate findings into clear hypotheses and next-step recommendations.
• Troubleshoot studies and refine methods to improve experimental quality, efficiency, and impact.
• Prioritize activities across projects and align work with team and company goals.
• Survey relevant scientific literature and incorporate new concepts or approaches into research plans.
• Prepare clear scientific reports and presentations for team meetings, collaborators, and leadership.
• Contribute to a collaborative, innovative, and scientifically rigorous team environment.

Knowledge and Skills

• Ability to design and execute complex experiments with a high degree of scientific rigor.
• Experience developing and applying biochemical and cellular assays.
• Strong understanding of related scientific discipline and relevant literature.
• Demonstrated productivity, experimental creativity, and effective problem solving.
• Ability to analyze multidimensional data and derive clear scientific conclusions.
• Strong written and verbal communication skills, including peer-directed presentations.
• Ability to work independently, design alternative approaches, and adapt to evolving project needs.
• Awareness of related scientific disciplines and ability to collaborate effectively in a cross-functional environment.

• Experience with patient-relevant cellular models or disease-relevant assay systems preferred.

Education & Experience

• Ph.D. in Cellular Biology, Biochemistry, Biophysics, Molecular Biology, or a related discipline; with 0-3 years of relevant post-doctoral experience; or
• Master's degree with 3+ years of relevant employment experience; or
• Bachelor's degree with 6+ years of relevant employment experience.

Pay Range:

$105,600 - $158,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]