Discovery DMPK Scientist (LC-MS Bioanalysis)

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 88,000 - 100,000; Full time

Job summary

Arrowhead Pharmaceuticals, Inc. in Madison, WI is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics within the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team.

You will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results with cross-functional colleagues. A successful candidate will have a BS in Biology with 8+ years of related experience (MS with 5+ years also

Qualifications

• Bachelor of Science in Biology or related field and a minimum of 8 years of experience in cell biology, molecular biology, immunology, pharmacology, or a related field of biology (Or Master’s degree and 5 years of experience)
• Experience in protein LC/MS and related laboratory techniques
• Excellent oral and written communication skills
• Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
• Proficient with Microsoft Suite Applications (i.e. Excel, Word)
• Demonstrated ability to learn and apply novel technologies

Responsibilities

• Perform LC-MS based quantitative bioanalysis in biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
• Support the identification of drug candidate metabolites.
• Process, review, and interpret data independently.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Understand experiment designs, generate figures to present data accordingly, and share bioanalysis results to cross-functional groups.
• Set up and maintain lab instruments.
• Maintain a well-documented laboratory notebook. Document experimental procedure and results accurately and meticulously.
• Demonstrate sample analysis, troubleshooting and problem-solving skills.
• Execute assays in a timely manner to meet deadlines.
• Be able to address questions or concerns related to bioanalysis running conditions and data analysis criteria.
• Adhere to safe laboratory practices.

Skills

LC-MS

Bioanalysis

Communication skills

Team player

Problem solving

Education

BS in Biology or related field

MS in Biology

Tools

Microsoft Excel

Mass spectrometry

Job description

Arrowhead Pharmaceuticals, Inc. in Madison, WI is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics within the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team.

You will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results with cross-functional colleagues. A successful candidate will have a BS in Biology with 8+ years of related experience (MS with 5+ years also