Director, Vector Biology

Legend Biotech; Philadelphia (Philadelphia County); On-site; USD 187,989 - 246,735; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

401(k) with company match

Paid Parental Leave

Flexible Spending Account

Short and Long-Term Disability

Pet Insurance

Commuter Benefits

Employee Assistance Program

Job summary

A leading biotechnology company is looking for a Director, Vector Biology to oversee lentiviral vector production and manage a team of scientists in Philadelphia. The ideal candidate will possess strong leadership skills and deep knowledge of viral vector technologies, contributing to innovative cell therapy solutions.

Qualifications

• Ph.D. required with 5+ years in cell and gene therapy.
• Experience with LVV manufacturing and team management.
• Strong understanding of CMC requirements.

Responsibilities

• Lead a team of 10+ scientists in Vector Biology.
• Oversee lentiviral vector production for research.
• Drive process development for LVV manufacturing.

Skills

Leadership

Viral Vector Technologies

Process Development

Collaboration

Education

Ph.D. in Chemical Engineering, Virology, Molecular Biology

Job description

5 days ago Be among the first 25 applicants

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Director, Vector Biology as part of the Exploratory Technology team based in Philadelphia, PA.

Role Overview

We are seeking a highly experienced and strategic leader to join our Vector Biology team as Director. This role will oversee lentiviral vector (LVV) production and early process development, while managing a team of 10+ scientists and collaborating cross-functionally with internal and external stakeholders.

Key Responsibilities

• Lead and manage a team of 10+ direct reports within the Vector Biology group.
• Oversee lentiviral vector (LVV) production to support internal research initiatives.
• Provide conventional vector core services to internal stakeholders.
• Drive early-stage process development for LVV manufacturing, including upstream, downstream, and analytical workflows.
• Set strategic direction for LVV Chemistry, Manufacturing, and Controls (CMC).
• Represent the Vector Biology team in cross-functional collaborations with Discovery Research, Early Drug Development (EDD), and Technical Development teams.
• Lead internal and external technology transfers for LVV manufacturing.
  
  
  

Requirements

• Ph.D. in Chemical Engineering, Virology, Molecular Biology, or a related field.
• Minimum of 5 years of industry experience in cell and gene therapy, with a focus on viral vector production.
• Proven leadership experience managing teams of 5 or more direct reports.
• Hands-on experience with LVV manufacturing using bioreactors and industrial-scale downstream processes.
• Strong understanding of CMC requirements for viral vectors.
• Deep knowledge and hands-on experience in viral vector technologies.
• Experience working with Contract Development and Manufacturing Organizations (CDMOs).
• Experience providing vector core services is a plus.
  
  
  

The anticipated base pay range for this is: $187,989 - $246,735 USD.

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

Benefits:

• Health Insurance
• Dental Insurance
• Vision Insurance
• Life Insurance
• Matched 401K
• Flexible Spending Account
• Health Savings Account
• AD&D Insurance
• Short-Term Disability
• Long-Term Disability
• Paid Maternity Leave
• Paid Paternity Leave
• Pet Insurance
• Critical Illness Insurance
• Hospital Indemnity Insurance
• Accident Insurance
• Legal Insurance
• Commuter Benefits
• Employee Assistance Program

Seniority level

• Seniority level

  Director

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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