Director, Transformation Enterprise Program Office

Worldwide Clinical Trials Holdings, Inc.; North Carolina; On-site; USD 146,000 - 289,000; Full time

Job summary

Worldwide Clinical Trials Holdings, Inc. is seeking a Director of Transformation Enterprise Program Office to lead a portfolio of high-impact initiatives within the Enterprise Program Management Office.

The role focuses on change management, CRO operations, and technology delivery, guiding project teams to realize value and alignment with enterprise goals. The ideal candidate brings a deep background in strategy execution, transformation, and AI-aware program delivery, with a track record of

Qualifications

• Bachelor’s degree in Finance, Economics, Accounting, Business Administration, Engineering, or a related field.
• Master’s degree or certifications in Agile, Change Management, or Lean Six Sigma are a plus.
• Minimum of 5 years of CRO and Life Sciences experience.
• Minimum of 12 years of experience in strategy execution, business transformation, digital program management, portfolio management, software technology implementation, change management, or a similar role within a large-scale EPMO or Transformation Office.
• Proven track record of managing a portfolio of complex projects and achieving strategic objectives.
• Demonstrated ability to identify and resolve complex organizational and project-related challenges.
• Strong executive presence with experience presenting to and communicating with senior leadership.
• Expertise in change management principles and their practical application in a corporate environment.
• Exceptional coaching, mentoring, and influencing skills.
• Adept at navigating complex global organizations.
• Familiarity with AI concepts and their application in business is highly desirable.
• Excellent written and verbal communication skills; able to influence and align stakeholders from frontline teams to executive leadership

Responsibilities

• Serve as the single point of contact for all projects within the assigned EPMO portfolio.
• Proactively engage with and support project teams to monitor progress and ensure successful delivery of value.
• Collaborate with Project Leaders to refine project plans and establish milestones and success metrics.
• Identify and help resolve blockers such as misalignment, resistance to change, and capability gaps.
• Prepare concise documentation for executive and board governance meetings.
• Lead post-mortems to capture lessons learned and drive continuous improvement.
• Integrate the portfolio into the overall EPMO, aligning with enterprise objectives.
• Coach Project Leaders on best practices for high-impact projects.
• Champion integration of AI into project methodologies and solutions.
• Provide access to resources, research, and analytical support for Project Leaders.
• May supervise direct reports.
• Perform other duties as assigned.

Skills

Leadership

Strategic thinking

Communication

Problem solving

Organizational skills

Portfolio management

Change management

AI awareness

Coaching & mentoring

Stakeholder management

Education

Bachelor's degree in Finance, Economics, Accounting, Business Administration or Engineering

Advanced certifications in Agile, Change Management or Lean Six Sigma

Job description

Who we are

We’re a global, midsize CRO that pushes boundaries, innovates and invents because the path to a cure for the world’s most persistent diseases is not paved by those who play it safe. It is built by those who take pioneering, creative approaches and implement them with quality and excellence. We are Worldwide Clinical Trials, and we are a global team of over 3,500+ experts, bright thinkers, dreamers and doers and, together, we are changing the way the world experiences CROs – in the best possible way. Our mission is to work with passion and purpose every day to improve lives and we are looking for others who value this same pursuit.

Why Worldwide

We believe everyone plays an important role in making a world of difference for patients and their caregivers. From our hands‑on, accessible leaders, to our cohesive and supportive teams, we are committed to enabling professionals from all backgrounds and experiences to succeed. We prioritize cultivating a diverse and inclusive environment that continues to promote collaboration and creativity. We are proud to be a workplace where people thrive by being themselves and are inspired to do their best work every day. Join us!

What the Director, Transformation Enterprise Program Office does at Worldwide

This is an opportunity to help a world‑class specialty Contract Research Organization (CRO) bring its deep scientific expertise to new customers and new markets. The Director, Transformation Enterprise Program Office is a pivotal role within the Enterprise Program Management Office (EPMO). This position acts as the strategic partner and driving force for a dedicated portfolio of EPMO projects. Each lead has a distinct area of deep expertise: Change Management: Focused on organizational readiness, stakeholder engagement, and adoption of new processes and tools. Contract Research Organization (CRO) Operations: Focused on enabling underlying process and technology improvements in a CRO context. Technology Delivery: Focused on guiding project teams to implement new technology across the enterprise. Each Portfolio Lead will own and manage a portfolio of high‑impact initiatives within their area of expertise, serving as the single point of contact for project teams. They will drive proactive planning, problem‑solving, capability building, and progress tracking to ensure the successful execution and value realization of the portfolio. While each role has a dedicated focus area, the Portfolio Leads will operate as a cohesive team, collaborating to align their portfolios, share insights, resolve cross‑cutting issues, and contribute to the overall success of the EPMO. A Portfolio Lead may have direct reports. This team‑based approach ensures that projects benefit from multidisciplinary expertise and a unified approach to execution. The ideal candidate is a master facilitator, strategist, and coach with deep expertise in their domain (Change Management, CRO Operations, or Technology Implementation), a strong track record of navigating complexity, and the ability to support and enable project leaders to succeed.

What you will do

• Serve as the single point of contact for all projects within the assigned EPMO portfolio
• Proactively engage with and support project teams to monitor progress and ensure the successful delivery of intended value and outcomes
• Collaborate with Project Leaders to refine overall project plans, including the establishment of critical milestones and success metrics
• Identify, analyze, and help resolve significant blockers to project success, such as lack of stakeholder alignment, fear of change, organizational capability gaps, etc.
• Prepare and develop clear, concise documentation for executive- and board-level governance meetings
• Lead comprehensive post-mortems to capture lessons learned and foster a culture of continuous improvement
• Integrate the assigned portfolio of projects into the overall EPMO, ensuring alignment with broader enterprise objectives
• Coach and mentor Project Leaders on best practices for executing successful, high-impact projects
• Champion and guide the integration of Artificial Intelligence (AI) into project methodologies and solutions
• Act as a key enabler of critical resources and support to Project Leaders, including access to expert interviews, targeted research, and analytical support
• May supervise direct reports, supporting their performance and development
• Perform other duties as assigned

The duties and responsibilities listed above are representative of the nature and level of work assigned and are not necessarily all-inclusive.

What you bring to the role

• Exceptional leadership and facilitation skills, with the ability to influence, motivate, and align cross‑functional teams toward a common vision
• Advanced strategic thinking, capable of synthesizing complex information and developing actionable plans that drive enterprise value
• Outstanding communication abilities, both written and verbal, with a proven aptitude for preparing executive-level documentation and delivering high‑impact presentations
• Superior problem‑solving and critical thinking skills, able to anticipate risks, analyze challenges from multiple perspectives, and implement effective solutions quickly
• Strong organizational acumen, including the ability to manage multiple projects simultaneously and prioritize competing demands in a dynamic environment
• Deep proficiency in project and portfolio management methodologies, Transformation Office techniques, tools, and best practices
• High emotional intelligence and the ability to foster a culture of trust, engagement, and continuous improvement
• Change management expertise, with a knack for guiding organizations through ambiguity and transformation
• Flexible and adaptable, thriving in fast‑paced, evolving environments, and embracing opportunities to innovate and learn
• Technological curiosity and literacy, especially as it relates to emerging trends in Artificial Intelligence (AI) and digital transformation

Your experience

• Bachelor’s degree in Finance, Economics, Accounting, Business Administration, Engineering, or a related field; Master’s degree or certifications in Agile, Change Management, or Lean Six Sigma are a plus
• Minimum of 5 years of Contract Research Organization (CRO) and Life Sciences experience
• Minimum of 12 years of experience in strategy execution, business transformation, digital program management, portfolio management, software technology implementation, change management, or a similar role within a large‑scale EPMO or Transformation Office
• Proven track record of managing a portfolio of complex projects and achieving strategic objectives
• Demonstrated ability to identify and resolve complex organizational and project-related challenges
• Strong executive presence with experience presenting to and communicating with senior leadership
• Expertise in change management principles and their practical application in a corporate environment
• Exceptional coaching, mentoring, and influencing skills
• Adept at navigating complex global organizations
• Familiarity with AI concepts and their application in business is highly desirable
• Excellent written and verbal communication skills; able to influence and align stakeholders from frontline teams to executive leadership

Files

The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates): United States of America - $145,500.00 - $288,500.00 The salary range provided is intended to give candidates an understanding of potential earnings. Compensation will fall within the provided range, and it not a guarantee of exact salary. The final salary will be determined based on relevant experience, performance, education, and internal equity. In addition to base salary, we offer a competitive benefits package depending on location. We ensure pay equity and transparency and comply with all applicable labor laws. Salary information will be discussed during the interview process, and we encourage candidates to inquire about compensation at any stage. We love knowing that someone is going to have a better life because of the work we do.

We are committed to fostering an inclusive and equitable workplace by providing transparent compensation.

To view our other roles, check out our careers page at Discover a world of difference at Worldwide! For more information on Worldwide, visit www.Worldwide.com or connect with us on LinkedIn.

This is who we are. We’re a team of clinicians, scientists, and researchers who want to make healthcare better. We were founded on an unwavering commitment to authentic, personalized attention. And today, as CROs consolidate and the industry changes rapidly, that personalized attention is more important than ever. We all came to this industry for different reasons, from different walks of life. If you ask any one of us why we’re here, you’ll get a different answer. And that’s what makes us special.