Director, Real World Evidence

Barrington James; Billerica (MA); On-site; USD 150,000 - 210,000; Full time

Job summary

You will lead studies using claims, EMR, registries, and federated data networks, with opportunity to contribute to AI/ML/NLP methods and external scientific representation.

Qualifications

• 8–10+ years of RWE experience in pharma, biotech or CRO.
• Master’s or PhD in Epidemiology, Public Health, HEOR, Biostatistics, or related field.
• Experience designing and leading studies using secondary RWD—claims, EMR, registries.
• Proven ability to independently develop and execute global RWE strategies.
• Strong understanding of drug development and cross-functional evidence generation.
• Experience with regulatory or payer submissions/interactions preferred.
• Background in Oncology, Neurology, or Immunology is a plus.
• Publications, conference presentations, advisory work or RWE thought leadership valued.
• HTA, PROs, AI/ML/NLP, vendor management, and budget oversight advantageous.

Responsibilities

• Own the RWE strategy for a high-priority global product/program.
• Collaborate with Global Program Teams and senior stakeholders to influence development decisions.
• Lead sophisticated RWE studies using diverse data sources and federated networks.
• Represent RWE externally through regulatory interactions, conferences and publications.
• Shape RWE methodology and strategy, including AI/ML/NLP opportunities.

Skills

RWE leadership

Stakeholder management

Scientific communication

Education

Master's or PhD in Epidemiology or related field

Tools

IQVIA

Optum

TriNetX

CPRD

OMOP/FHIR

Job description

This is an opportunity for a senior RWE scientist to step into a highly visible scientific leadership role and own the Real-World Evidence strategy for a complex, high-priority product or portfolio.

Rather than being focused solely on study execution, you’ll have the opportunity to shape the evidence strategy from the ground up, working directly with Global Program Teams and senior stakeholders across Clinical Development, Regulatory, Medical, Market Access, and Commercial.

You’ll have the scientific autonomy to lead complex RWE programs end-to-end — from identifying the right data sources and designing studies through execution, interpretation, regulatory engagement, publications, and external scientific representation. No direct reports — but significant scientific ownership, visibility, and influence.

• Own the RWE strategy for a high-priority global product/program.
• Work directly with senior cross-functional and global stakeholders and influence key development and business decisions.
• Lead sophisticated RWE studies using claims, EMR, registries, and federated data networks.
• Have visibility across the product lifecycle, including clinical development, regulatory strategy, Market Access, and commercial evidence generation.
• Represent the organization externally through regulatory interactions, conferences, publications, and industry collaborations.
• Help shape the future of RWE methodology, including opportunities involving AI/ML, NLP, and emerging data sources.
• Serve as a scientific mentor and recognized RWE subject-matter expert within the organization.

Qualifications

• 8–10+ years of RWE experience within pharma, biotech, or a CRO.
• Master’s or PhD in Epidemiology, Public Health, HEOR, Biostatistics, or related field.
• Deep experience designing and leading studies using secondary RWD — claims, EMR, registries, etc.
• Experience with platforms such as IQVIA, Optum, TriNetX, CPRD and/or OMOP/FHIR.
• Proven ability to independently develop and execute global RWE strategies.
• Strong understanding of drug development and cross-functional evidence generation.
• Experience with regulatory or payer submissions/interactions strongly preferred.
• Background in Oncology, Neurology, or Immunology is a plus.
• Publications, conference presentations, advisory work, or other RWE thought leadership highly valued.
• Additional experience with HTA, PROs, AI/ML/NLP, vendor management, and budget oversight is advantageous.

For an experienced RWE scientist looking to move beyond study execution, this role offers the chance to become a key scientific voice for a global program, with the autonomy to shape strategy, influence decision-making, and represent RWE at the highest levels of the organization.