Director, Protein Sciences

Jobtailor; Massachusetts; On-site; USD 180,000 - 240,000; Full time

Job summary

Jobtailor in Massachusetts seeks a senior scientific leader to guide biologics discovery from target to lead identification. You will drive target evaluation, data integration, and design strategies for antibodies and engineered proteins, leveraging AI/ML tools to accelerate discovery.

The role requires a PhD with 10+ years in biologics, strong leadership, and excellent communication. Applicants should thrive in a fast-paced, matrix environment and collaborate across Oncology, Immunology, and

Qualifications

• PhD in Biochemistry, Structural Biology, Protein Engineering or related field.
• At least 10 years in biologics discovery or protein sciences.
• Demonstrated leadership within pharma/biotech.
• Strong knowledge in antigen design, structural biology, and biologics workflows.
• Experience or domain knowledge in Oncology, Immunology, Neuroscience preferred.
• People management experience preferred.
• Excellent verbal and written communication skills.
• Strategic with a strong scientific mindset.
• Ability to operate in a fast-paced matrix environment.

Responsibilities

• Lead evaluation of therapeutic targets using structural, sequence, and domain architecture analysis.
• Integrate internal and external data from literature, databases, and structural repositories.
• Define antigen and engineered-cell design strategies to support antibody discovery, including nanodisc tech and immunogen design.
• Apply computational and structural biology approaches to protein design, including homology modeling and rational mutagenesis.
• Integrate emerging AI/ML-based protein design tools.
• Engineer proteins to improve stability and expression for discovery assays and immunization.

Skills

Leadership

Strategic mindset

Scientific communication

Cross-functional collaboration

Education

Ph.D. in Biochemistry/Structural Biology/Protein Engineering

Job description

Responsibilities

• Lead evaluation of therapeutic targets, including structural, sequence, and domain architecture analysis.
• Integrate internal and external data (literature, databases, structural repositories).
• Define antigen and engineered-cell design strategies to support antibody discovery: construct design and domain selection, epitope exposure and conformational state optimization, strategies for difficult targets (e.g., multi-pass membrane proteins) including nanodisc technology and nucleic acid immunogen design.
• Apply computational and structural biology approaches to protein design: homology modeling, structural analysis, and rational mutagenesis.
• Integrate emerging AI/ML-based protein design tools.
• Engineer proteins to improve stability and expression, functional relevance for discovery assays and immunization.

Requirements

• A minimum of a Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related discipline.
• A minimum of 10 years of experience in biologics discovery or protein sciences.
• Demonstrated leadership experience within the pharmaceutical or biotech industry.
• Strong knowledge in: antigen design and generation for antibody discovery; structural biology and protein sequence analysis; biologics discovery workflows from target to lead identification.
• Experience or domain knowledge in Oncology, Immunology, and/or Neuroscience is preferred.
• People management experience is preferred.
• Excellent verbal and written communication skills.
• Strategic with a strong scientific mindset.
• Ability to operate effectively within a highly coordinated, fast-paced matrix environment.

Core Competencies

Expertise in protein engineering and structural biology, with a strong focus on antigen design and biologics discovery workflows. Proven leadership in the pharmaceutical or biotech industry, complemented by excellent communication skills and the ability to thrive in fast-paced environments.