Director, Portfolio Strategy & Governance.

Genentech; San Francisco (CA); On-site; USD 160,000 - 298,000; Full time

Benefits offered by this job

Discretionary annual bonus

Job summary

Genentech, based in South San Francisco, CA, seeks a Director to shape and lead the portfolio strategy and governance for Digital Finance. You will design the portfolio operating model, establish governance, and drive disciplined execution across a matrixed enterprise to deliver measurable business value.

The role requires extensive experience in portfolio leadership, enterprise transformation, and stakeholder management, with a focus on aligning investments to strategic priorities and enabling

Qualifications

• 10+ years in portfolio or program leadership.
• Experience building portfolio operating models.
• Transformation across tech and processes.
• Strategic-to-execution leadership.
• Ability to connect strategy to value.
• Executive-level stakeholder leadership.
• Experience in matrixed, regulated environments.
• PMP/PgMP/SAFe certification valued.

Responsibilities

• Define and evolve the Digital Finance portfolio strategy and operating model.
• Lead structured intake and prioritization for opportunities.
• Own end-to-end portfolio view: roadmap, milestones, dependencies, risks.
• Partner with leaders to balance value, demand, and capacity.
• Establish governance forums and decision logs.
• Drive cross-functional alignment and accountability across matrixed teams.
• Track performance measures and portfolio value realization.
• Provide visibility into spend and investments across contractors and tools.

Skills

Portfolio leadership

Governance

Stakeholder management

Strategic planning

Executive partnering

Education

Bachelor’s degree + MBA/MS preferred

Job description

The Position

Director, Portfolio Strategy & Governance

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.

The Opportunity:

The Director, Portfolio Strategy & Governance will shape and lead the portfolio operating model for Digital Finance, creating the transparency, prioritization, governance, and accountability needed to translate digital strategy into measurable business outcomes.

This leader will own the end-to-end portfolio strategy and governance framework across a diverse portfolio spanning enterprise platforms and ERP stabilization, data and analytics, AI, automation, process optimization, and data governance. Working across Finance, technology, data, and global teams, the Director will establish how opportunities are evaluated and prioritized, how investments and capacity are aligned to strategic priorities, and how progress, risks, dependencies, and value are surfaced to leadership.

This role requires a leader who can move fluidly between strategy and execution - designing the portfolio operating model while ensuring governance mechanisms, decision forums, and operating rhythms translate into disciplined execution, adoption, and measurable value. The Director will lead primarily through influence, creating alignment and accountability across a highly matrixed enterprise environment.

Key Roles & Responsibilities:

Portfolio Strategy & Prioritization

• Define and evolve the Digital Finance portfolio strategy and operating model, ensuring the portfolio remains aligned to business priorities and enterprise direction.

• Design and lead a structured intake and prioritization approach for capturing, triaging, scoring, and approving opportunities, balancing strategic value, demand, risk, dependencies, and available capacity.

• Own the end-to-end portfolio view, including roadmap, milestones, interdependencies, resourcing, risks, investment needs, and key decisions.

• Partner with leaders to make portfolio trade-offs and ensure resources and investments are focused on the highest-value priorities.

Governance & Operating Model

• Establish and lead governance forums, portfolio reviews, intake councils, escalation pathways, decision rights, and decision logs to enable timely, transparent decision-making.

• Define portfolio and delivery standards, including expectations for documentation, status reporting, templates, operating cadences, and, where appropriate, agile or sprint-based practices.

• Create clear mechanisms for managing cross-portfolio dependencies, risks, issues, and decisions, driving resolution and accountability across workstreams.

• Ensure major changes and portfolio decisions are documented with the appropriate traceability to support internal controls, compliance, and audit readiness.

Performance & Value Realization

• Establish an outcome-based portfolio performance and value realization framework that connects initiatives to measurable business outcomes.

• Define and track relevant measures such as time savings, cycle-time reduction, error reduction, adoption, service-level improvements, and other agreed business outcomes.

• Support portfolio-level business case and investment tracking while maintaining visibility into spend across contractors, vendors, tools, and other portfolio investments.

• Use portfolio insights to identify delivery trends, risks, capacity constraints, and opportunities to improve execution and realized value.

Executive & Cross-Functional Leadership

• Serve as a strategic partner to Digital Finance and business leaders, translating complex portfolio information into clear insights, choices, and recommendations.

• Coordinate across Finance, IT, data governance, architecture, global teams, and other enterprise partners to maintain alignment with standards, roadmaps, and governance cadences.

• Partner with change, communications, and business owners to ensure effective rollout, training alignment, adoption, and sustained outcomes.

• Lead through influence by setting the operating cadence, coaching workstream leads, facilitating decisions, and driving accountability across matrixed teams while fostering transparency and disciplined execution.

Who You Are:

• Education: Bachelor’s degree in Finance, Business, Operations, Industrial Engineering, Information Systems, or a related field; MBA/MS preferred.

• Experience: 10+ years of progressive experience in portfolio or program leadership, enterprise transformation, strategy and operations, transformation governance, enterprise PMO, finance transformation, or a related discipline.

• Portfolio leadership: Demonstrated experience building or materially evolving portfolio operating models, including intake, prioritization, governance forums, decision rights, capacity planning, and portfolio-level performance management.

• Transformation breadth: Proven track record leading or governing complex portfolios that span technology and process transformation, such as enterprise platforms/ERP, data and analytics, automation, AI, or operating-model change.

• Strategic and operational leadership: Ability to connect enterprise strategy to execution while creating the structures, operating rhythms, and accountability needed to deliver outcomes.

• Value orientation: Experience establishing outcome measures and connecting portfolio investments and delivery performance to business value and adoption.

• Stakeholder leadership: Strong executive presence with demonstrated ability to facilitate decisions, influence senior stakeholders, navigate competing priorities, and build alignment across functions without relying on direct authority.

• Enterprise environment: Experience operating in complex, matrixed organizations; experience in regulated or controlled environments with strong documentation, traceability, and compliance requirements is preferred.

• Certifications: PMP, PgMP, SAFe, Prosci, or equivalent portfolio/program/change certification is valued but not required.

Location:

This position is based in South San Francisco, CA.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of San Francisco, CA is $160,300- $297,700. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.