Director of Protein Biochemistry

Pacific Biosciences; United States; On-site; USD 196,000 - 294,000; Full time

Job summary

Pacific Biosciences seeks a Director of Protein Biochemistry to lead protein engineering and single-molecule biochemistry efforts for its long-read sequencing platforms. This role directs a five-person, multidisciplinary team spanning biochemistry, engineering, microscopy, biophysics, enzymology, and computational analysis.

The candidate will establish scientific priorities, guide characterizations, and collaborate with cross-functional partners to translate research into platform improvements.

Qualifications

• PhD in biochemistry, biophysics, molecular biology, bioengineering, or related field.
• 15+ years of industry experience.
• 10+ years of management experience leading scientific teams.
• Strong knowledge of protein and nucleic acid chemistry, structural biology, and sequencing technologies.

Responsibilities

• Direct protein engineering and single-molecule biochemistry research to develop and optimize proteins and biochemical systems for PacBio's sequencing platforms.
• Lead, mentor, and develop a five-person multidisciplinary team across experimental, engineering, and computational disciplines.
• Establish scientific priorities, research plans, and milestones aligned with sequencing platform development goals.
• Guide protein biochemical characterization, single-molecule biophysical measurements, and enzymology studies to inform engineering strategies.
• Integrate microscopy, biochemical measurements, and computational analyses to guide experimental design and decisions.
• Collaborate with cross-functional partners to translate research findings into platform performance improvements.

Skills

Protein engineering

Biochemistry

Single-molecule biochemistry

Biophysics

Education

PhD in biochemistry, biophysics, molecular biology, bioengineering, or a closely related discipline

Tools

Single-molecule microscopy

Enzymology

Job description

Director of Protein Biochemistry

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

Position Summary

PacBio is seeking a Director of Protein Biochemistry to lead protein engineering and single-molecule biochemistry efforts supporting the development and advancement of its long-read, single-molecule sequencing platforms. This individual will direct a five-person multidisciplinary team with expertise in protein biochemistry, protein engineering, single-molecule microscopy, biophysics, enzymology, and computational and statistical analysis.

Responsibilities

• Direct protein engineering and single-molecule biochemistry research to develop and optimize proteins and biochemical systems for PacBio's long-read, single-molecule sequencing platforms.
• Lead, mentor, and develop a five-person team spanning experimental, engineering, and computational disciplines.
• Establish scientific priorities, research plans, and milestones aligned with sequencing platform development goals.
• Guide protein biochemical characterization, single-molecule biophysical measurements, and enzymology studies to understand performance and inform engineering strategies.
• Integrate microscopy, biochemical measurements, and computational and statistical analyses to guide experimental design and research decisions.
• Collaborate with cross-functional partners to translate research findings into improvements in sequencing platform performance.
• Communicate research progress, technical challenges, and recommendations to scientific collaborators and leadership.

Required Qualifications

• PhD in biochemistry, biophysics, molecular biology, bioengineering, or a closely related discipline.
• At least 15 years of relevant industry experience.
• At least 10 years of management experience leading scientific or technical teams.
• Strong knowledge of protein and nucleic acid chemistry, structural biology, single-molecule biophysical analysis, genomic analysis, and next-generation sequencing technologies.
• Experience directing protein engineering and biochemical research programs.
• Ability to guide multidisciplinary teams and integrate experimental findings with quantitative analysis.
• Excellent interpersonal, written, and verbal communication skills.

Preferred Experience

• Experience applying AI and/or machine learning methods as applied to protein engineering, biochemical research, or sequencing data analysis.
• Bioinformatics expertise relevant to genomic analysis and sequencing technologies.

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

Salary Range

$195,900.00 - $293,900.00

To all Staffing and Recruiting Agencies

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All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on th