Director of Immunology & Translational Drug Discovery

PsiThera, Inc.; Watertown (MA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

401k match

Competitive salary

Impactful work

Job summary

PsiThera, Inc. is seeking an experienced drug discovery biologist to lead immune and inflammatory signaling programs from hit identification through DC nomination and IND submission.

You will balance program leadership with hands-on lab work, building and running the research plan, mentoring scientists, and driving key experiments to milestones in inflammation and autoimmunity models. You will collaborate with CROs, shape translational strategies, and present program updates to senior leadership

Qualifications

• PhD in Immunology or related field with 12+ years biotech/pharma drug discovery experience.
• Track record of advancing small molecules from hit identification to DC selection as project team leader or lead biologist.
• Hands-on experience in hit finding, including screening assay development, HTS or DEL campaigns, and hit triage and confirmation.
• Prior people management experience and demonstrated leadership of cross-functional project teams or workstreams.
• Hands-on expertise with primary human immune cells and whole blood, and in building assay cascades for screening, SAR and mechanism-of-action studies.
• Broad knowledge of in vitro and in vivo models of inflammation and autoimmunity, with experience designing and interpreting in vivo pharmacology and PK/PD studies.
• Experience managing CRO collaborations.
• Scientific achievement shown through peer-reviewed publications and/or patents.

Responsibilities

• Lead program teams from hit identification through DC nomination and IND submission.
• Develop and manage research plans, budgets, risks and milestones for programs.
• Oversee hit finding campaigns (HTS/DEL) and assay cascades for screening and SAR.
• Design and run in vitro pharmacology studies using human cells and whole blood; oversee in vivo studies.
• Mentor scientists and build in-house capabilities; engage with CROs and external experts.
• Present program progress to senior leadership and partners.

Skills

Immunology expertise

Drug discovery

Project leadership

In vitro pharmacology

Team mentoring

Scientific communication

Education

PhD in Immunology

Tools

HTS

DEL

Job description

PsiThera, Inc. is seeking an experienced drug discovery biologist to lead immune and inflammatory signaling programs from hit identification through DC nomination and IND submission.

You will balance program leadership with hands-on lab work, building and running the research plan, mentoring scientists, and driving key experiments to milestones in inflammation and autoimmunity models. You will collaborate with CROs, shape translational strategies, and present program updates to senior leadership