Director of Drug Substance Engineering & Materials Science

Vertex Pharmaceuticals Inc (US); Boston (MA); On-site; USD 170,000 - 254,000; Full time

Job summary

Vertex is seeking a talented individual to join the Engineering and Materials Science (EMS) department in Boston, MA. The successful candidate will lead a diverse team of engineers and scientists to develop and scale‑up drug substance processes, from early development through to commercialization.

You will drive cross‑functional collaboration, apply process modeling, and mentor junior staff, with a focus on robust manufacture of small molecules or oligonucleotides and transfer to manufacturing

Qualifications

• BS/MS/PhD in Chemical Engineering or closely related field with relevant pharmaceutical experience.
• Experience mentoring junior scientists and leading cross‑functional teams.
• Knowledge of unit operations in small molecule and oligonucleotide drug substance development, including particle engineering, kinetics, thermodynamics, and transport.

Responsibilities

• Lead and develop a cross‑functional team to define, develop, and demonstrate multi‑step syntheses for robust manufacture from clinical development through commercialization.
• Lead drug substance process development, drive assets via lab development, modeling, drug supply prep, and tech transfer to third‑party facilities.
• Collaborate with materials development, process chemistry, analytical development, and formulation to optimize drug substance properties and performance.

Skills

Mentoring junior scientists

Process modeling

Data analysis

Statistical design of experiments

Scale-up

Education

BS Degree in Chemical Engineering

MS Degree in Chemical Engineering

PhD in Chemical Engineering

Job description

Vertex is seeking a talented individual to join the Engineering and Materials Science (EMS) department in Boston, MA. The successful candidate will lead a diverse team of engineers and scientists to develop and scale‑up drug substance processes, from early development through to commercialization.

You will drive cross‑functional collaboration, apply process modeling, and mentor junior staff, with a focus on robust manufacture of small molecules or oligonucleotides and transfer to manufacturing