Director, Medical Analytics and Exploratory Data Science

Revolution Medicines; San Francisco (CA); On-site; USD 211,000 - 264,000; Full time

Job summary

A late-stage oncology company in San Francisco is seeking a highly motivated Director of Biostatistics to lead statistical initiatives in clinical development. The role requires a Ph.D. or M.S. in Biostatistics with extensive experience in the biotech/pharma industry. Responsibilities include providing strategic statistical leadership, collaborating with cross-functional teams, and mentoring junior statisticians. The salary range for this position is between $211,000 and $264,000, reflecting the expertise needed in oncology statistics and real-world evidence.

Qualifications

• Minimum of 8 years of experience (Ph.D.) or 12 years (M.S.) in the biotech/pharma industry.
• Solid knowledge of statistical methodologies for oncology.
• Hands-on experience in exploratory analysis of oncology trials.

Responsibilities

• Provide statistical leadership for exploratory data analyses.
• Serve as the primary statistical contact for assigned projects.
• Lead the design and interpretation of complex statistical models.
• Manage relationships with external partners and CROs.
• Mentor junior statisticians and foster scientific rigor.

Skills

Statistical methodologies for oncology

Survival analysis

Causal inference

Independent project leadership

SAS

R

Communication skills

Project management skills

Education

Ph.D. or M.S. in Statistics/Biostatistics

Tools

SAS

R

Job description

Revolution Medicines is a late‑stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

We are seeking a highly motivated and scientifically rigorous Director of Biostatistics to our Medical Analytics and Exploratory Data Science Biostatistics group. This role will provide strategic and hands‑on statistical leadership for exploratory data analyses, scientific publications, real‑world evidence (RWE), post‑marketing research, and health economics and outcomes research (HEOR) initiatives. The successful candidate will serve as a key statistical leader and individual contributor, partnering closely with cross‑functional teams to generate high‑quality evidence that advances our oncology pipeline and supports medical and scientific strategy.

• Provide statistical leadership for exploratory data analyses using existing clinical trial data, real world data studies, post‑marketing research, and HEOR projects.
• Serve as a primary statistical contact for assigned projects, working collaboratively with clinical development, medical affairs, safety, statistical programming, regulatory affairs and commercial.
• Lead the design, analysis, and interpretation of complex statistical models, including survival analysis, machine learning, and causal inference methodologies.
• Contribute to and implement policies, standards, and procedures to ensure consistency and quality in statistical practices.
• Manage relationships with external partners, such as contract research organizations (CROs), ensuring adherence to timelines, budgets, and quality standards.
• Mentor and provide technical guidance to junior statisticians, fostering scientific rigor, innovation, and professional growth.
• Contribute to regulatory and payers/HTA agencies interactions, scientific publications, abstracts, and internal decision‑making through clear and effective communication of statistical results.

Required Skills, Experience and Education

• Ph.D. or M.S. in Statistics/Biostatistics, a minimum of 8 years (for Ph.D.) and 12 years (for M.S.) of experience in biotech/pharma industry as a statistician.
• Solid knowledge of statistical methodologies for oncology, including survival analysis and causal inference.
• Hands‑on experience in exploratory analysis of oncology trials.
• Proven ability to independently lead statistical aspects of complex, cross‑functional projects.
• Strong understanding of regulatory requirements related to biostatistical activities and clinical trials.
• Excellent verbal and written communication skills are required.
• Excellent interpersonal and project management skills are essential.
• Proficiency in SAS and/or R.

Preferred Skills

• Knowledge of RWD and health economics and outcomes research (HEOR) in oncology is a plus.
• Familiarity with machine learning or advanced modeling approaches applied to biomedical or observational data.

Base Pay Salary Range

$211,000 - $264,000 USD

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.