Director, Head of Incentive Compensation & Execution Excellence

Alnylam Pharmaceuticals, Inc.; United States; Remote; USD 204,000 - 276,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

401(k) with company match

Paid time off and holidays

Wellness days and recharge breaks

Job summary

Alnylam Pharmaceuticals seeks a Director of Sales Execution & Enablement to design, operationalize, and drive adoption of incentive compensation programs and field enablement initiatives. This role partners with Sales Leadership, Finance, HR, Training, and Field Enablement to align incentives, tools, and coaching with priorities and frontline execution.

The position leads annual/quarterly planning, develops scalable solutions, and oversees IC/PC programs, with ~10% travel to support external and

Qualifications

• Bachelor’s degree or better.
• 10+ years of experience in Incentive Compensation, Field Enablement, and / or Commercial Effectiveness.
• Proven experience designing and operationalizing incentive compensation plans tied to behavior and execution.
• Strong understanding of sales motions, frontline execution, and manager led coaching.
• Experience defining and using KPIs to drive adoption and performance change.
• Ability to translate data into actionable insights.
• Exceptional stakeholder management and communication skills.
• Experience leading, coaching, and developing dynamic teams of high performing individuals.
• Capable presenter to executive audiences.
• Track record of delivering solutions with excellent attention to detail, accuracy, and derived value.
• High sense of urgency, balanced with focus on quality & process.
• Project management skills with demonstrated ability to lead multiple projects & priorities.
• Ability to travel for key external & internal meetings as needed (Role requires ~10% overnight travel).

Responsibilities

• Design and manage incentive compensation plans that drive field behaviors and execution.
• Translate business goals into defined success measures and KPI targets.
• Collaborate with Finance, HR, Legal, Compliance, and Sales to ensure compliant, scalable plans.
• Lead annual and quarterly compensation planning cycles with scenario modeling.
• Own plan communication, field readiness, and ongoing interpretation for adoption.
• Ensure enablement tied to incentives is measurable and KPI-linked.
• Oversee incentive and bonus programs to ensure executable, compliant outcomes.
• Provide leadership for IC and PC programs with field leadership and Finance.
• Develop leading and lagging KPIs to measure execution quality and outcomes.
• Work with Advanced Analytics to build dashboards for reps, managers, and leaders.
• Monitor performance trends and translate insights into action for leaders.

Skills

Incentive compensation

Field enablement

Commercial effectiveness

Sales motions

KPIs and metrics

Data translation

Stakeholder management

Executive presentation

Project management

Travel readiness

Education

Bachelor’s degree or better

Job description

Overview:

The Director of Sales Execution & Enablement is responsible for designing, operationalizing, and driving adoption of incentive compensation programs and field enablement initiatives that improve execution, behavior change, and measurable performance outcomes. This role sits at the intersection of incentive compensation, field enablement, and execution excellence, ensuring that compensation plans and enablement efforts translate into consistent field execution and KPI attainment.

The role partners closely with Sales Leadership, Finance, HR, Training, and Field Enablement to align incentives, tools, and coaching with company priorities and frontline execution.

Key Responsibilities:

• Incentive Compensation Strategy & Execution
• Design and manage incentive compensation plans that drive desired field behaviors, execution excellence, and strategic priorities
• Translate business goals into clearly defined measures of success, including quantifiable targets and performance metrics
• Partner with Finance, HR, Legal, Compliance, and Sales to ensure incentive compensation plans are compliant, scalable, and financially sound
• Lead annual and quarterly compensation planning cycles, including scenario modeling and performance forecasting
• Own compensation plan communication, field readiness, and ongoing interpretation to ensure clarity and adoption
• Ensure enablement efforts tied to incentive compensation are measurable, behavior based, and linked to KPIs
• Provide strategic oversight of all incentive and bonus programs to ensure they are executable, motivating, compliant, and fiscally responsible
• Lead the accurate and timely execution of incentive compensation plans, including payout calculations, documentation, and governance
• Define and drive short and long term solutions for incentive compensation administration, enabling scalable capabilities, tools, and technology to support a growing and increasingly complex field organization; partner with Commercial Enablement, IT, and other internal teams to deliver these solutions
• Provide strategic leadership for the Incentive Compensation (IC) and President’s Club (PC) programs in close partnership with field leadership, HR, and Finance
• Make data driven recommendations on compensation design and goal setting methodologies, informed by modeling, testing, and validation
• Conduct regular IC health checks (e.g., goal attainment and payout distributions, advantaged/disadvantaged segments) to ensure plans perform in line with design objectives
• Develop clear, effective materials to communicate plan designs to field teams, including design documents, IC statements, ranking reports, and payout estimators
• Define and operationalize leading and lagging KPIs that measure execution quality, adoption, and outcomes
• Work closely with Advanced Analytics team to build dashboards and reporting that provide actionable insights at the rep, manager, and leadership levels
• Monitor performance trends to identify risks, opportunities, and coaching needs
• Translate insights into targeted actions for leaders and frontline managers
• Enable frontline managers with coaching frameworks, performance insights, and incentive literacy
• Partner with Sales Leadership and training to embed coaching into operating rhythms, e.g., QBRs
• Support managers in diagnosing performance issues and reinforcing behaviors tied to incentives and enablement
• Promote a culture of continuous improvement, accountability, and data driven coaching

Qualifications:

• Bachelor’s degree or better
• 10+ years of experience in Incentive Compensation, Field Enablement, and / or Commercial Effectiveness
• Proven experience designing and operationalizing incentive compensation plans tied to behavior and execution
• Strong understanding of sales motions, frontline execution, and manager led coaching
• Experience defining and using KPIs to drive adoption and performance change
• Ability to translate data into actionable insights
• Exceptional stakeholder management and communication skills
• Experience leading, coaching, and developing dynamic teams of high performing individuals.
• Capable & proven presenter to executive audiences.
• Track record of delivering solutions with excellent attention to detail, accuracy, and derived value.
• High sense of urgency, balanced with focus on quality & process.
• Project management skills with demonstrated ability to lead multiple projects & priorities.
• Ability to travel for key external & internal meetings as needed (Role requires ~10% overnight travel).

About Alnylam

We are the leader in RNAi therapeutics– a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam’s Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

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The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:https://www.alnylam.com/careers

U.S. Pay Range

$204,000—$276,000 USD