Director, Downstream Processing & Scale-Up (CDMO/CMO)

Debut Biotech

San Diego (CA)

On-site

USD 170,000 - 230,000

Full time

14 days+

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Job summary

Debut Biotech is seeking an Associate Director/Director of Downstream Processing to lead strategy and execution of purification processes for fermentation‑derived products. You will guide a team of scientists and engineers through bench, pilot, and manufacturing scale while managing external CDMO/CMO partnerships from proposal to tech transfer and commercial scale‑up.

The role requires deep expertise in downstream unit operations and strong cross‑functional collaboration to deliver

Qualifications

Significant downstream process development experience for fermentation‑derived products.
Experience guiding bench, pilot, and manufacturing scales.
Proven ability to lead technical teams and mentor scientists/engineers.
Experience authoring and executing technology transfers to CDMO/CMO.
Strong communication with technical and non‑technical stakeholders.

Responsibilities

Direct development of downstream purification processes from bench to manufacturing scale.
Lead CDMO/CMO partnerships, proposals, site visits, and tech transfer.
Serve as technical PM for scale‑up projects, ensuring timelines and budgets.
Provide experimental, modeling, and statistical support for transfers.
Collaborate with quality, regulatory, and supply chain teams.