Crystallization Scientist (Contract)

Vertex Pharmaceuticals; Boston (MA); On-site; USD 83,000 - 87,000; Part time

Job summary

Vertex Pharmaceuticals in Boston, MA is seeking a temporary contract engineer to support drug substance process development on bench scale, focusing on early crystallization and particle engineering for commercially viable API products.

The candidate will work in a multidisciplinary team applying chemistry and chemical engineering principles, with experience in API crystallization, DOE concepts, and lab instrumentation. Strong communication and organization skills are required.

Qualifications

• MS/BS degree with 2–5 years in the pharmaceutical industry.
• Life science concentration preferred in chemical engineering or chemistry.
• Experience in API process development and scale-up, esp. crystallization and particle engineering.
• Strong fundamentals in chemistry/chemical engineering; familiarity with lab instrumentation.
• Experience with DOE and QbD concepts; familiarity with modeling tools.

Responsibilities

• Support drug substance process development on bench scale.
• Develop early fit-for-purpose API crystallizations for viable particle forming processes.
• Develop crystallization, isolation, drying, size reduction and other particle engineering operations.

Skills

Design of Experiments

QbD concepts

Interdisciplinary teamwork

Communication skills

Lab automation tools

Education

MS/BS degree in life sciences

Chemical engineering or chemistry concentration preferred

Tools

Aspen

Dynochem

Matlab

HPLC

GC

FTIR

Raman

FBRM

DSC

TGA

XRPD

Job description

Job Description

Job Summary

Vertex is seeking a talented individual to join ourEngineering and Materials Sciencesgroup in Boston, MA on a temporary contract basis.

Engineering and Materials Sciencesat Vertex plays a vital role in bridging the gap between new pharmaceutical discoveries and commercial products. Engineers at Vertex work in multidisciplinary scientific teams to bring basic medical discoveries to patients and physicians by applying fundamental chemistry and chemical engineering principles to new products, processes, and development technologies.

The successful candidate will be a highly productive, results-oriented individual, able to generate and implement original ideas and solutions that contribute materially to the success and development of drug substance candidates.Strong communication, organization, and planning skills anda high levelof technical aptitude and creativity arerequiredfor success in this position.

Job Description

The successful candidate will be responsible for:

• Supporting drug substance process development on a laboratory/bench scale,and in particular, developinganddemonstratingearly fit-for-purpose API crystallizations leading to commerciallyviableAPI particle forming processes. These would include the development of crystallization, isolation, drying, sizereductionand other particle engineering operations.

Basic and Preferred Qualifications include:

• MS/BS degree with 2 - 5 years of pharmaceutical industry experience. Degrees with a life science concentrationrequired, with a preference for concentrations in chemical engineering or chemistry.
• Knowledge and experience in API process development and scale up, in particular small molecule crystallization and particle engineering operations.
• A demonstrated understanding and working knowledge of chemistry and chemical engineering fundamentals; applied kinetics, thermodynamics, and transport fundamentals; as well as familiarity with modern laboratory instrumentation (HPLC, GC, FTIR, Raman, FBRM, DSC, TGA, XRPD,etc) and common laboratory automation tools.
• Experience with statistical design ofexperiments;QbDconcepts;and familiarity with common physical property and process modeling tools (Aspen,Dynochem,Matlab, etc.).
• The ability to successfully interact and collaborate within an interdisciplinary team environmentcomprisedof organic, physical, and analytical chemists, project team members, and manufacturing personnel.
• Proven communication (verbal and written) and interpersonal skills.

Pay Range

$60-$63/HR

Requisition Disclaimer

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

No C2C or Third-Party Vendors