Cryo-EM Structural Biologist for Neurodegenerative Disease Research

University of California - San Francisco; San Francisco (CA); On-site; USD 55,000 - 195,000; Full time

Job summary

University of California, San Francisco seeks a Specialist in Structural Biology to decipher the structural basis of neurodegenerative diseases and solve high-resolution cryo-EM/ET structures of disease-relevant proteins. The IND cryo-EM facility includes Titan Krios G4, Glacios, L120C TEM, and a Helios Hydra FIB-SEM at UCSF’s Mission Bay campus.

The successful applicant will be an expert in structural biology, collaborating across disciplines to advance cryo-EM research and contribute to drug

Qualifications

• Bachelor or higher in Chemistry, Biophysics, or related field; for junior/assistant/associate roles relevant experience.
• Ten or more years for senior levels may apply; technical qualifications required.

Responsibilities

• Solve high-resolution cryo-EM/ET structures of disease-relevant protein macromolecules.
• Collaborate with IND/UCSF teams to advance cryo-EM research for neurodegenerative disease biology.
• Apply methods to support drug discovery and related research efforts.

Skills

Cryo-EM expertise

Cryo-ET experience

Protein structure determination

Atomic-resolution methods

Education

Bachelor/Master/PhD in Chemistry/Biophysics or related

4+ years research experience

Tools

SerialEM

EPU

Scipion

RELION

cryoSPARC

Job description

University of California, San Francisco seeks a Specialist in Structural Biology to decipher the structural basis of neurodegenerative diseases and solve high-resolution cryo-EM/ET structures of disease-relevant proteins. The IND cryo-EM facility includes Titan Krios G4, Glacios, L120C TEM, and a Helios Hydra FIB-SEM at UCSF’s Mission Bay campus.

The successful applicant will be an expert in structural biology, collaborating across disciplines to advance cryo-EM research and contribute to drug