Cryo-EM Structural Biologist for Neurodegeneration Research

University of California, San Francisco; San Francisco (CA); On-site; USD 55,000 - 194,800; Full time

Job summary

University of California, San Francisco (UCSF) seeks a Specialist in Structural Biology to decipher structural bases of neurodegenerative diseases, including AD, FTD, MSA, and PD. The role focuses on solving high-resolution structures, including co-structures with therapeutic targets, using cryo-EM/ET and related techniques.

The successful applicant will work in the IND cryo-EM facility, collaborate across disciplines, and contribute to drug discovery efforts under the direction of the IND and

Qualifications

• Bachelor/Master/PhD in chemistry/biophysics or related field with relevant research experience.
• 2+ years in cryo-EM/cryo-ET or high-resolution protein structure methods.
• Experience with cryo-EM software and data processing tools.

Responsibilities

• Determine atomic-resolution structures of protein macromolecules for drug discovery.
• Operate and support cryo-EM/ET experiments and data analysis.
• Collaborate with multidisciplinary teams across UCSF and IND.

Skills

Cryo-EM

Cryo-ET

Computational analysis

X-ray crystallography

NMR

Education

Bachelor's degree in Chemistry or Biophysics

Master's degree in Chemistry or Biophysics

PhD in Chemistry or Biophysics

Terminal degree in Chemistry or Biophysics

Tools

SerialEM

EPU

Scipion

RELION

cryoSPARC

Job description

University of California, San Francisco (UCSF) seeks a Specialist in Structural Biology to decipher structural bases of neurodegenerative diseases, including AD, FTD, MSA, and PD. The role focuses on solving high-resolution structures, including co-structures with therapeutic targets, using cryo-EM/ET and related techniques.

The successful applicant will work in the IND cryo-EM facility, collaborate across disciplines, and contribute to drug discovery efforts under the direction of the IND and