Contractor, Drug Metabolism and Pharmacokinetics (DMPK)

PTC Therapeutics, Inc; Bridgewater Township (NJ); On-site; USD 62,000 - 96,000; Full time

Job summary

PTC Therapeutics, Inc, a global biopharmaceutical company, seeks a Contractor for Drug Metabolism and Pharmacokinetics (DMPK) to plan and perform metabolism/bioanalysis assays in discovery and early development.

The position supports cross-functional project teams, adheres to SOPs, and contributes to regulatory compliance. It requires a Master’s or higher in related fields and 2–4+ years of experience in pharma/biotech environments.

Qualifications

• Master's or Bachelor's degree with required experience in pharma/biotech environments.
• Demonstrated experience in in vitro and in vivo DMPK studies (metabolic stability, CYP inhibition/induction).
• Experience operating LC-MS instruments and troubleshooting LC-MS workflows.
• Ability to work independently and in cross-functional teams in a fast-paced setting.

Responsibilities

• Initiates and executes scientific research and experiments as part of multi-disciplinary teams.
• Performs established in vitro and in vivo metabolism/bioanalysis assays.
• Develops new DMPK assays and improves existing ones.
• Documents results, maintains lab records, and prepares study reports.
• Ensures compliance with safety, regulatory guidelines, and SOPs.
• Supports general lab needs including equipment maintenance and capital purchases.

Skills

Independent work

Team collaboration

Analytical thinking

Problem-solving

Time management

Strong communication

Education

Master's degree in Biology / Chemistry / Biochemistry / Pharmaceutical Science / Pharmacology or related field

Bachelor's degree with 4+ years relevant experience

Tools

LC-MS instruments

Automated liquid handlers

Liquid handling robots

Microsoft Office

Job description

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

Job Description Summary

The Contractor, Drug Metabolism and Pharmacokinetics (DMPK) plans and performs in vitro and in vivo metabolism/bioanalysis assays in support of DMPK studies in discovery and early development.
The Contractor, DMPK interprets data and communicates experimental results to his/her supervisor and colleagues.
The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC's discovery science project teams.
The Contractor, DMPK supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.
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Job Description

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

• With guidance, initiates and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s).
• Performs and maintains established in vitro and in vivo metabolism/bioanalysis assays.
• With guidance, develops new, and improves upon existing DMPK assays.
• Performs hands-on in vitro and in vivo metabolism/bioanalysis assays using LC-MS/MS.
• Documents experiment details in lab books, records results in database and prepares study reports.
• Abides by all safety and regulatory guidelines.
• Performs other tasks and assignments as needed or specified by management.
• Contributes to general lab needs such as:
  • Equipment maintenance and/or troubleshooting.
  • Capital equipment purchases.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

* Minimum level of education and years of relevant work experience.

• A Master's degree in Biology, Chemistry, Biochemistry, Pharmaceutical Science, Pharmacology or other related scientific discipline and a minimum of 2 years of relevant and progressively responsible experience in a pharmaceutical, biotechnology or similar environment OR a Bachelor's degree in these same disciplines and a minimum of 4 years of the same experience.

* Special knowledge or skills needed and/or licenses or certificates required.

• Demonstrated experience in conducting in vitro and in vivo DMPK studies, such as metabolic stability in liver microsomes and hepatocytes, CYP inhibition and induction, and bioanalysis in various matrices etc.
• Demonstrated experience in operating and troubleshooting contemporary LC-MS instruments and automated liquid handlers.
• Hands-on experience with liquid handlers, LC-MS instruments and other equipment.
• Detailed knowledge of DMPK and applied techniques.
• Experience with developing and optimizing relevant DMPK assays.
• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment that may consist of both internal and external team members.
• Proficiency with Microsoft Office.
• Good verbal and written communication skills.
• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects

*Special knowledge or skills and/or licenses or certificates preferred.

• Knowledge of drug metabolism and pharmacokinetics in discovery preclinical research.

* Travel requirements

• Up to 5%
• Office/Laboratory based position

Expected Hourly Range:

$45-$70/hour. The hourly salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity.

EEO Statement

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.