Computational Protein Design Intern for Agricultural Biotech

Syngenta AG; Durham (NC); Sur place; USD 28 000 - 62 000; Plein temps

Avantages offerts par ce poste

Competitive wages

Professional development resources

Ongoing career development resources

Meaningful, innovative projects

Résumé du poste

Syngenta invites a Bioinformatics Intern to join the Protein Design team in Durham, NC. You will work within a high-performance scientific group, applying computational protein design to generate novel candidates and minibinders for targeted proteins.

The Emerging Talent Program offers hands-on experience, exposure to day-to-day operations, and opportunities to apply academic knowledge to real-world agricultural biotech challenges. Duration: May 2027 to August 2027.

Qualifications

• Current MS or PhD student in Bioinformatics, Computational Biology, Structural Biology, Biochemistry, Computer Science, or related field.
• Proficiency in Python and basic Bash scripting.
• Basic understanding of protein structure concepts, including protein domains, structural alignment, and protein-protein interfaces.
• Familiarity with protein structure prediction methods such as Boltz-2 or AlphaFold.
• Familiarity with generative protein design or sequence design tools such as RFdiffusion or ProteinMPNN.
• Familiarity with protein structure visualization tools (PyMOL).
• Experience with Linux/Unix command-line environments.

Responsabilités

• Leverage open-source protein design and structure prediction workflows using tools such as ProteinMPNN, BoltzGen, and Boltz-2.
• Design, rank, and filter protein candidates based on predicted structure, interface quality, and computational metrics.
• Perform structural analysis and annotation of designed proteins and protein-protein interfaces.
• Test and run computational protein design tools in Linux, HPC, or cloud-based environments such as AWS.
• Develop Python/Bash scripts for data processing, workflow automation, and visualization.
• Document workflows, create user guides and READMEs, and present findings to cross-functional teams.
• Collaborate with and take guidance from other scientists to refine design strategy based on biological insights.
• Summarize design results in clear reports, visualizations, and recommendations for follow-up testing.

Connaissances

Python

Bash scripting

Linux/Unix

Formation

MS or PhD student in Bioinformatics/Computational Biology/Structural Biology/Biochemistry/CS

Outils

ProteinMPNN

BoltzGen

Boltz-2

PyMOL

AWS

Description du poste

Syngenta invites a Bioinformatics Intern to join the Protein Design team in Durham, NC. You will work within a high-performance scientific group, applying computational protein design to generate novel candidates and minibinders for targeted proteins.

The Emerging Talent Program offers hands-on experience, exposure to day-to-day operations, and opportunities to apply academic knowledge to real-world agricultural biotech challenges. Duration: May 2027 to August 2027.