Computational Medicinal Chemist

Novartis Group Companies; Cambridge (MA); On-site; USD 119,000 - 223,000; Full time

Job summary

An established industry player is seeking a computational scientist to join a vibrant CADD team in Cambridge. This role involves leveraging machine learning and AI to drive drug discovery, collaborating with multidisciplinary teams to develop innovative solutions. You'll design medicinal chemistry efforts and conduct mechanistic studies, all while contributing to groundbreaking medicines. If you're passionate about transforming biomedical research and have a strong background in computational chemistry or related fields, this opportunity is perfect for you.

Qualifications

• Advanced degree in computational chemistry, physics, or biology required.
• 2+ years of experience in drug discovery with project teams.

Responsibilities

• Design medicinal chemistry efforts using SAR and predictive methods.
• Lead hypothesis generation and molecular design for drug candidates.

Skills

Machine Learning

AI Integration

Data Visualization

Communication Skills

Team Leadership

Education

Advanced degree in Computational Chemistry

Advanced degree in Physics

Advanced degree in Biology

Tools

Drug Design Tools

High-Performance Computing

Job description

Job Description Summary

Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse talents to redefine the way biomedical research teams validate and develop new targets. We are a driving force behind drug discovery and are seeking an exceptional computational scientist to join our ranks.

Imagine the opportunity to unlock hidden knowledge and disruptive insights from vast data collected by a renowned pharmaceutical company. We need your expertise, experience, and passion to help us extract this wealth of information. Collaborating with a multidisciplinary team, you will craft innovative solutions to pressing drug discovery challenges, paving the way for groundbreaking medicines.

Job Details

• Internal Job Title: Senior Expert I/Senior Expert II, Data Science
• Location: Cambridge, MA, onsite

Responsibilities

1. Design medicinal chemistry efforts using knowledge of SAR, target biology, and predictive methods for assessing activity, properties, PK/PD, and synthetic feasibility; familiarity with molecular dynamics, free energy calculations, solvation tools, quantum chemical calculations is a plus.
2. Apply expertise in machine learning and AI to small molecule/cyclic peptide drug discovery, integrating digital technologies with experimental data.
3. Stay updated with scientific literature and collaborate with internal and external scientists to incorporate biological insights into lead characterization and screening.
4. Work with interdisciplinary teams to facilitate decision-making from target identification to candidate nomination, developing predictive models related to activity and ADME properties.
5. Lead hypothesis generation and molecular design to improve clinical success rates for small molecules and cyclic peptides.
6. Conduct cross-disciplinary mechanistic studies using physics-based modeling, biophysical characterization, and cellular validation to inform strategic targeting and mechanisms of action.

Minimum Requirements

1. Advanced degree in computational chemistry, physics, biology, or related fields; candidates with a laboratory background and strong computational skills are encouraged.
2. At least 2 years of experience in a drug discovery environment working with project teams.
3. Proven track record of innovation impacting discovery projects.
4. Familiarity with drug design tools, high-performance computing, and a strong publication record.

Skills and Abilities

• Proactive with a clinical focus.
• Rigorous in idea substantiation, design, and experimentation.
• Team-oriented with multitasking and leadership capabilities.
• Excellent communication skills, both written and oral.
• Proficient in data visualization and insight communication.

Why Join Us

Our purpose is to reimagine medicine to improve lives. We value our people, who drive us daily towards our ambitions. Join us and be part of shaping the future of medicine.

Learn more about our culture: https://www.novartis.com/about/strategy/people-and-culture

Benefits

Find detailed benefits and rewards information in the Novartis Life Handbook.

Compensation

Salary range: $119,700 - $222,300 for Senior Expert I, and $132,300 - $245,700 for Senior Expert II. Final salary depends on experience, location, and other factors. Compensation may include bonuses, stock units, and benefits.

Additional Information

Join our network to stay connected: https://talentnetwork.novartis.com/network

Equal Opportunity Statement

We are an EEO employer and do not discriminate based on race, gender, age, or other protected statuses.

Accessibility

We provide reasonable accommodations for individuals with disabilities. Contact us at [e-mail].