Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist

Vertex Pharmaceuticals; Boston (MA); On-site; USD 153,000 - 231,000; Full time

Job summary

An innovative biotechnology company is seeking a skilled Senior Principal Scientist specializing in synthetic peptide chemistry. In this pivotal role, you will engage in the synthesis and purification of organic compounds and peptides, driving forward innovative strategies in a collaborative environment. Your expertise will contribute to the development of cutting-edge therapies, while you maintain high standards of scientific excellence. This is a unique opportunity to be part of a dynamic team, where your contributions will significantly impact the future of healthcare and patient outcomes. Join a company that values scientific innovation and provides a supportive environment for professional growth.

Benefits

Medical Benefits

Dental Insurance

Vision Insurance

Generous Paid Time Off

Educational Assistance Programs

401(k) Matching

Commuting Subsidy

Company Shutdown Weeks

Annual Bonus

Equity Awards

Qualifications

• 6-8 years of experience in synthetic organic chemistry or peptide chemistry.
• Experience managing external CROs/CMOs and nucleic acid modifications.

Responsibilities

• Synthesize, purify, and characterize small organic compounds and peptides.
• Collaborate with project teams and manage relationships with external partners.

Skills

Organic Synthesis

Solid-Phase Peptide Synthesis (SPPS)

Analytical Data Interpretation

Communication Skills

Education

PhD in Chemistry

MS in Chemistry

Tools

HPLC

NMR

Mass Spectrometry (MS)

Job description

Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist

Join to apply for the Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist role at Vertex Pharmaceuticals

Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist

8 hours ago Be among the first 25 applicants

Join to apply for the Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist role at Vertex Pharmaceuticals

Get AI-powered advice on this job and more exclusive features.

Direct message the job poster from Vertex Pharmaceuticals

Talent Acquisition Associate Director at Vertex Pharmaceuticals

Job Description

General Summary:

Vertex is seeking an experienced peptide chemist to join the Process Chemistry group. In this lab-based position you will be responsible for the synthesis, purification, and characterization of small organic compounds, peptides and possibly peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs). In addition, you will be responsible for any tech transfer to external CMOs for phase appropriate development and scale-up.

Key Duties And Responsibilities

• Responsible for the synthesis, purification, and characterization of small organic compounds, peptides, and oligonucleotides under minimal supervision
• Manage relationships with external partners
• Identify and advocate for innovative synthetic strategies to project teams
• Collaborate with project teams in a cross-functional environment
• Author or contribute to technical documents including regulatory submissions, patents, and scientific papers
• Maintain a high level of expertise via relevant scientific and technical literature, and proactively apply new ideas to research projects.
  
  

Knowledge And Skills

• Strong expertise in organic synthesis, especially solid-phase peptide synthesis (SPPS)
• Developing and scaling-up solid phase and liquid phase chemistry
• Experience with reverse-phase and/or ion-exchange purification of small molecules or peptides
• Strong organizational and communication skills
  
  

Education And Experience

• PhD 6-8 years of experience, or MS degree with 9 years or experience (or equivalent education and experience) in synthetic organic chemistry or peptide chemistry Experience managing external CROs/CMOs
• Experience in nucleic acid modifications and delivery of oligonucleotides are highly desirable
• Experience with small- and large-scale CS-Bio solid phase peptide synthesizers (CS136x, CS936, or equivalent) in non-GMP and GMP environments
• Experience with the synthesis, conjugation and purification of phosphorodiamidate morpholino oligomers (PMOs) is highly desired
• Experience independently planning, executing experiments, and interpreting analytical data (H/UPLC, NMR, MS, etc.
  
  

Keywords: Oligonucleotide, process chemistry, solid-phase synthesis, peptide synthesis

Pay Range

$153,600 - $230,400

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

Referrals increase your chances of interviewing at Vertex Pharmaceuticals by 2x

Get notified about new Principal Chemist jobs in Boston, MA.

Principal Scientist, Chemistry Automation

Boston, MA $137,000.00-$215,270.00 2 weeks ago

Chemistry Lead Scientist - Center for Therapeutic Discovery

Research Associate/Sr. Research Associate - Chemistry

Senior Principal Scientist I, Lab Head Medicinal Chemistry

Chemistry Lead Scientist - Center for Therapeutic Discovery

Senior Analytical Chemist - Solid State Characterization

Senior Scientist, Computational Chemistry

Principal Scientist, Medicinal Chemistry

Boston, MA $150,000.00-$160,000.00 3 weeks ago

Principal Scientist, Medicinal Chemistry - 5 yrs Industry Exp, Small Molecule - Durham, NC Requires Relocation

Principal Process Chemist (Manufacturing)

Scientist/Senior Scientist, Oligonucleotide Sciences Analytical Chemistry

Senior Scientific Fellow, Process Chemistry

Senior Scientific Fellow, Process Chemistry

Medical Laboratory Scientist, Senior I - Chemistry

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.