Computational Genomics Scientist — Spatial & Multiomics (Hybrid)

Vertex Pharmaceuticals; Boston (MA); Hybrid; USD 112,000 - 168,000; Full time

Benefits offered by this job

Hybrid work arrangement

On-site option

Job summary

Vertex Pharmaceuticals in Boston is seeking a Computational Genomics Research Scientist to advance cell and gene therapies. You will design studies, run bulk and single-cell sequencing analyses, and generate biological insights that drive early research across disease programs.

You will collaborate with stem cell biology, immunology, gene editing, and pre-clinical teams; apply spatial transcriptomics and multi-omic approaches; ensure reproducible workflows and clear communications.

Qualifications

• Experience analyzing genomic and NGS data
• Strong visualization, interpretation of results
• Ability to translate complex findings for broad audiences

Responsibilities

• Collaborate closely with cross-functional research teams to identify key scientific questions that can be addressed through genomics, sequencing, and bioinformatics approaches.
• Lead the application and advancement of spatial transcriptomics methods, collaborating across teams and sites to develop, implement, and share analytical best practices.
• Analyze and integrate diverse genomic datasets, including bulk RNA-seq, single-cell profiling, spatial transcriptomics, and other multiomic datasets to generate actionable insights.
• Perform sophisticated computational analyses of sequencing and other biological data through deep critical thinking, incorporation of published findings and best practices from the field, strong statistical rigor, and data science visualizations
• Distill complex analyses and scientific results into key take-home messages and recommendations for next steps to a broad audience.
• Partner with computational and software teams to improve analytical workflows, reproducibility, usability, and robustness.
• Practice reproducible research and maintain well-documented, version-controlled analytical workflows.
• Author study reports and technical documentation to support research and regulatory activities.
• Evaluate emerging genomics technologies and computational methods and incorporate new approaches where appropriate.

Skills

Single-cell genomics

Spatial transcriptomics

Genomic data analysis

Data visualization

Statistics

Biology knowledge

Education

PhD in computational biology or related

Master's in related field

Tools

Python

R

Linux HPC

Bioconductor

Cloud computing

Job description

Vertex Pharmaceuticals in Boston is seeking a Computational Genomics Research Scientist to advance cell and gene therapies. You will design studies, run bulk and single-cell sequencing analyses, and generate biological insights that drive early research across disease programs.

You will collaborate with stem cell biology, immunology, gene editing, and pre-clinical teams; apply spatial transcriptomics and multi-omic approaches; ensure reproducible workflows and clear communications.