Computational Genomics Research Scientist

Vertex Pharmaceuticals; Boston (MA); Hybrid; USD 112,000 - 168,000; Full time

Benefits offered by this job

Hybrid work arrangement

On-site option

Job summary

Vertex Pharmaceuticals in Boston is seeking a Computational Genomics Research Scientist to advance cell and gene therapies. You will design studies, run bulk and single-cell sequencing analyses, and generate biological insights that drive early research across disease programs.

You will collaborate with stem cell biology, immunology, gene editing, and pre-clinical teams; apply spatial transcriptomics and multi-omic approaches; ensure reproducible workflows and clear communications.

Qualifications

• Experience analyzing genomic and NGS data
• Strong visualization, interpretation of results
• Ability to translate complex findings for broad audiences

Responsibilities

• Collaborate closely with cross-functional research teams to identify key scientific questions that can be addressed through genomics, sequencing, and bioinformatics approaches.
• Lead the application and advancement of spatial transcriptomics methods, collaborating across teams and sites to develop, implement, and share analytical best practices.
• Analyze and integrate diverse genomic datasets, including bulk RNA-seq, single-cell profiling, spatial transcriptomics, and other multiomic datasets to generate actionable insights.
• Perform sophisticated computational analyses of sequencing and other biological data through deep critical thinking, incorporation of published findings and best practices from the field, strong statistical rigor, and data science visualizations
• Distill complex analyses and scientific results into key take-home messages and recommendations for next steps to a broad audience.
• Partner with computational and software teams to improve analytical workflows, reproducibility, usability, and robustness.
• Practice reproducible research and maintain well-documented, version-controlled analytical workflows.
• Author study reports and technical documentation to support research and regulatory activities.
• Evaluate emerging genomics technologies and computational methods and incorporate new approaches where appropriate.

Skills

Single-cell genomics

Spatial transcriptomics

Genomic data analysis

Data visualization

Statistics

Biology knowledge

Education

PhD in computational biology or related

Master's in related field

Tools

Python

R

Linux HPC

Bioconductor

Cloud computing

Job description

Job DescriptionWe are seeking a Computational Genomics Research Scientist to support the development of transformative cell and gene therapies across Vertex's research portfolio. This Boston-based position is part of the global Data and Computational Sciences organization and will collaborate closely with research teams spanning stem cell biology, immunology, gene editing, and pre-clinical development to design studies, execute and analyze complex genomic analyses, and ultimately generate biological insights that drive early research across multiple disease programs. As an embedded computational scientist, you will be responsible for performing bulk and single-cell sequencing analyses , spatial transcriptomics, and multiomic profiling to help uncover the molecular programs that govern therapeutic cell identity, differentiation, function, and safety to accelerate the development of next-generation cell and gene therapies.This is a Boston based, hybrid position requiring 3 days/week onsite.Key ResponsibilitiesCollaborate closely with cross-functional research teams to identify key scientific questions that can be addressed through genomics, sequencing, and bioinformatics approaches.Lead the application and advancement of spatial transcriptomics methods, collaborating across teams and sites to develop, implement, and share analytical best practices.Analyze and integrate diverse genomic datasets, including bulk RNA-seq, single-cell profiling, spatial transcriptomics, and other multiomic datasets to generate actionable insights.Perform sophisticated computational analyses of sequencing and other biological data through deep critical thinking, incorporation of published findings and best practices from the field, strong statistical rigor, and data science visualizationsDistill complex analyses and scientific results into key take-home messages and recommendations for next steps to a broad audience.Partner with computational and software teams to improve analytical workflows, reproducibility, usability, and robustness.Practice reproducible research and maintain well-documented, version-controlled analytical workflows.Author study reports and technical documentation to support research and regulatory activities.Evaluate emerging genomics technologies and computational methods and incorporate new approaches where appropriate.Knowledge and Skills:A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) dataSolid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biologyExpertise with applying computational methods and bioinformatics tools to large-scale dataSolid understanding of statisticsEducation and Experience:Ph.D. in computational biology, bioinformatics, genomics, systems biology, biomedical engineering, statistics, computer science, or a related quantitative discipline, with 0-3 years of relevant postdoctoral or industry experience; or a Master's degree in a related field with 3+ years of relevant industry experience.Demonstrated expertise in the design, analysis, visualization, and interpretation of single-cell genomics and spatial transcriptomics experimentsProficiency in Python and/or R for scientific computing and data analysis.Experience working in Linux-based high-performance computing (HPC) and/or cloud computing environments.Strong foundation in statistics, experimental design, and reproducible computational research.Proven ability to derive biological insight from complex datasets and translate findings into actionable recommendations for research teams.Excellent communication and presentation skills, with the ability to effectively convey complex scientific findings to multidisciplinary audiences.Demonstrated ability to work collaboratively within cross-functional teams and contribute to a positive, team-oriented environment.#LI-KM1#LI-HybridPay Range:$112,000 - $168,000Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex Designation:Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:In this Hybrid-Eligible role, you can choose to be designated as:1. Hybrid : work remotely up to two days per week; or select2. On-Site : work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-HybridCompany InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]