Computational Chemistry Senior Research Scientist

Vertex Pharmaceuticals; San Diego (CA); Hybrid; USD 123,000 - 186,000; Full time

Job summary

Vertex Pharmaceuticals seeks a highly motivated Computational Chemistry Senior Research Scientist to enhance drug discovery efforts in San Diego. You will leverage your expertise to optimize lead compounds while collaborating with interdisciplinary teams and improving computational capabilities across the department.

Benefits

Annual bonus

Equity awards

401(k) matching

Medical, dental, and vision benefits

Generous paid time off

Educational assistance programs

Commuting subsidy

Qualifications

• Strong experience in molecular modeling methods.
• Expert knowledge of computational chemistry applications in drug discovery.
• 2-5 years of relevant post-doctoral experience preferred.

Responsibilities

• Collaborate to maximize computational efforts on drug discovery projects.
• Ensure effective communication for in-silico drug discovery work.
• Incorporate new methodologies in drug discovery.

Skills

Molecular modeling

Cheminformatics

Data analysis

Communication

Education

Ph.D. in engineering, science or math

Master's Degree in similar fields

Bachelor's Degree in similar fields

Tools

Commercial molecular modeling software

Job description

Computational Chemistry Senior Research Scientist

Join to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals

Computational Chemistry Senior Research Scientist

Join to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals

Job Description

We are seeking a highly motivated Computational Chemistry Senior Research Scientist to join Vertex’s research site in San Diego, California. This individual will be responsible for contributing to both lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. This individual will work collaboratively with interdisciplinary project teams to provide expertise in cheminformatics, physics-based methods, and molecular design to deliver drug candidates. Contributing to improving foundational computational capabilities across the department is preferred and achieved through collaboration with the global DCS group.

Job Description

We are seeking a highly motivated Computational Chemistry Senior Research Scientist to join Vertex’s research site in San Diego, California. This individual will be responsible for contributing to both lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. This individual will work collaboratively with interdisciplinary project teams to provide expertise in cheminformatics, physics-based methods, and molecular design to deliver drug candidates. Contributing to improving foundational computational capabilities across the department is preferred and achieved through collaboration with the global DCS group.



Responsibilities

• Collaborate with scientists at our San Diego drug discovery site and across our network to maximize the impact of computational efforts on drug discovery projects
• Ensure effective interdepartmental communication and implementation of in-silico work streams related to drug discovery
• Work with others in Computational Drug Design and the Chemical Data Science group to identify and apply new methodologies to increase impact of computation on drug discovery teams
• Incorporate innovative strategies and methodologies to address critical project issues
  
  

Education And Experience

• Ph.D. (or equivalent degree) in engineering, science or math and 2-5 years of productive, relevant post-doctoral employment experience, or
• Master's Degree (or equivalent degree) in similar fields and 5+ years of productive, relevant employment experience, or
• Bachelor's Degree (or equivalent degree) in similar fields and 8+ years of productive, relevant employment experience
• Strong experience in applying molecular modeling methods to structure, ligand and fragment-based drug discovery
• Expert knowledge of the state-of-the-art for computational chemistry and its application in drug discovery, such as FEP and ML techniques
• Experience with commercial molecular modeling and data mining software
• Excellent oral and written communication skills
• Ability to multi-task and set priorities on multiple projects
• Preferred Requirements
• Expertise with a wide array of computational methods preferably including structure and ligand-based virtual screening, programming, statistics, data analysis, QSAR derivation and application, and ADME modeling
  
  

Pay Range

$123,400 - $185,100

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as:

• Hybrid: work remotely up to two days per week; or select
• On-Site: work five days per week on-site with ad hoc flexibility.
  
  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Seniority level

• Seniority level

  Not Applicable

Employment type

• Employment type

  Full-time

Job function

• Job function

  Other

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