Computational Biologist — AI‑Driven Antibody Design

Socket.dev; Indianapolis (IN); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Multiple relocation packages

Two weeklong shutdowns (mid-summer and

8-week parental leave

9 Employee Resource Groups

Annual bonus offering

Flexible work arrangements

Up to 6% 401K matching

Job summary

Elanco, a global animal health leader, seeks a Research Scientist – Computational Biologist to advance AI-driven design of antibodies and proteins. You will work with AlphaFold, Rosetta, and other tools to accelerate our biologics pipeline, collaborating closely with wet-lab teams to validate predictions and iterate designs.

You will apply de novo design and structure-based ML methods, tackle developability challenges, and stay at the forefront of AI-driven biotherapeutics in a hybrid work

Qualifications

• Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Computer Science, or related field.
• 0-3 years post-graduate experience applying computational methods to biological problems.
• Strong foundation in structural bioinformatics and AI/ML modeling, with proficiency in Python and cross-functional communication.

Responsibilities

• Utilize and develop AI-driven tools (e.g., AlphaFold, Rosetta) to predict and design high-resolution structures of antibodies and other proteins, supporting the biologics pipeline.
• Apply generative AI and structural modeling to design novel antibody and protein modalities from scratch, optimizing them for epitopes, affinity, and specificity.
• Identify and engineer out liabilities (aggregation, immunogenicity) and train structure-based ML architectures to improve developability.
• Collaborate with wet-lab scientists to analyze data, validate predictions, and iterate on designs to accelerate antibody selection.
• Stay current with AI landscape, document efforts thoroughly, and communicate findings to cross-functional teams.

Skills

Structural bioinformatics

AI/ML modeling

Python

Communication

Education

Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Computer Science, or related field

Tools

AlphaFold

Rosetta

Job description

Elanco, a global animal health leader, seeks a Research Scientist – Computational Biologist to advance AI-driven design of antibodies and proteins. You will work with AlphaFold, Rosetta, and other tools to accelerate our biologics pipeline, collaborating closely with wet-lab teams to validate predictions and iterate designs.

You will apply de novo design and structure-based ML methods, tackle developability challenges, and stay at the forefront of AI-driven biotherapeutics in a hybrid work