Clinical Trial Manager

Oncology Voice Network LLC; Boston (MA); Hybrid; USD 120,000 - 150,000; Full time

Benefits offered by this job

Health Care Plan (Medical, Dental &amp

Vision

Retirement Plan (401k, IRA)

Life Insurance (Basic, Voluntary & AD&

Paid Time Off (Vacation, Sick & Public

Family Leave (Maternity, Paternity)

Short Term & Long Term Disability

Training & Development

Free Food & Snacks

Wellness Resources

Stock Option Plan

Job summary

Frontier Medicines in Boston, MA is seeking two Clinical Trial Managers to support day-to-day execution of our oncology trials. You will partner with CROs and trial sites, oversee feasibility, site selection, start-up, maintenance, and close-out, and contribute to study strategy.

This hybrid role requires 2–3 days onsite weekly with travel to trial sites as needed. Candidates should have 3–4 years in CTM/CPM roles, oncology experience preferred, and strong ICH-GCP knowledge.

Qualifications

• 3-4 years of Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology clinical trials.
• Experience supporting oncology studies strongly preferred.
• Legally authorized to work in the United States.

Responsibilities

• Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
• Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
• Assist with oversight of CRO and vendor set-up, liaising with CROs to ensure timely study initiation.
• Review site-level regulatory documents (e.g., Informed Consent Forms, essential documents) and escalate to appropriate stakeholders as needed.
• Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
• Proactively identify potential operational challenges and, in partnership with senior team members, propose mitigation plans.
• Coordinate Clinical Trial Team meetings and drive action item follow-up.
• Maintain clinical operations trackers, databases, and document repositories.
• Provide regular study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.

Skills

Clinical trial management

Oncology trials

Vendor/CRO management

ICH-GCP knowledge

Regulatory compliance

Communication skills

Organization / time management

Education

Bachelor's degree or RN

Job description

# Clinical Trial ManagerFrontier Medicines · Boston, MAVisit company websiteFULL-TIMEPosted Sep 14, 2026## Job DescriptionFrontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance of our Director/Sr. Director, Clinical Operations, you will serve as a key operational contact for our CROs and trial sites, helping drive feasibility assessments, site selection, start-up, maintenance, and close-out. This is a great opportunity for someone who wants hands-on ownership of trial execution at a growing, clinical-stage biotech, with direct exposure to program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA office, with an expectation of 2-3 days per week onsite, plus periodic travel to trial sites and CRO/vendor meetings as needed. Requirements What will you be doing? • Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out. • Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed. • Assist with oversight of CRO and vendor set-up, liaising with CROs to ensure timely study initiation. • Review site-level regulatory documents (e.g., Informed Consent Forms, essential documents) and escalate to appropriate stakeholders as needed. • Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements. • Proactively identify potential operational challenges and, in partnership with senior team members, propose mitigation plans to keep study execution on track. • Assist with review of protocols, master template informed consent forms, case report forms, and other clinical study documents as needed. • Monitor study performance metrics, timelines, and deliverables, and review CRO trip reports for trends and quality issues. • Track study budgets and vendor invoices/change orders in partnership with Clinical Operations and Finance, flagging discrepancies as needed. • Help maintain timely and accurate study registration and updates on ClinicalTrials.gov and other applicable registries. • Coordinate Clinical Trial Team meetings and drive action item follow-up. • Maintain clinical operations trackers, databases, and document repositories. • Provide regular study updates to internal stakeholders and support enrollment, database lock, and study closeout activities. Traits We Believe Make a Strong Candidate • Bachelor's degree in a scientific, healthcare, or related field, or an RN, required. • 3-4 years of Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology clinical trials. • Experience supporting oncology studies strongly preferred. • Vendor and CRO management experience. • Strong working knowledge of ICH-GCP guidelines and clinical trial regulations. • Excellent organizational, problem-solving, and time management skills, with strong attention to detail. • Strong written and verbal communication skills with a collaborative, team-oriented approach. • Comfortable in a fast-paced, dynamic environment; a proactive, roll-up-your-sleeves mindset. • Legally authorized to work in the United States. Benefits • Health Care Plan (Medical, Dental & Vision) • Retirement Plan (401k, IRA) • Life Insurance (Basic, Voluntary & AD&D) • Paid Time Off (Vacation, Sick & Public Holidays) • Family Leave (Maternity, Paternity) • Short Term & Long Term Disability • Training & Development • Free Food & Snacks • Wellness Resources • Stock Option Plan At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $120,000 - $150,000 Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits. This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.